ArticleDevelopmental biology2014
Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Article
- The genomes of a monogenic fly: views of primitive sex chromosomes.Scientific reports · 2020Article
- Daughterless, theDisease models & mechanisms · 2020Article
- Rb-independent E2F3 promotes cell proliferation and alters expression of genes involved in metabolism and inflammation.FEBS open bio · 2017Article
- Distinct regulation of atonal in a visual organ of Drosophila: Organ-specific enhancer and lack of autoregulation in the larval eye.Developmental biology · 2017Article
- Article
- ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.Journal of cell science · 2016Article
- Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons.Cell reports · 2016Article
- Introducing Pitt-Hopkins syndrome-associated mutations of TCF4 to Drosophila daughterless.Biology open · 2015Article
- Groucho restricts rhomboid expression and couples EGFR activation with R8 selection during Drosophila photoreceptor differentiation.Developmental biology · 2015Article
- ato-Gal4 fly lines for gene function analysis: Eya is required in late progenitors for eye morphogenesis.Genesis (New York, N.Y. : 2000) · 2015Article
- The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function.Protein & cell · 2015Article
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Authors and funding
5 authors.
Funding
Abstract
Class I Basic Helix-Loop-Helix (bHLH) transcription factors form homodimers or heterodimers with class II bHLH proteins. While bHLH heterodimers are known to have diverse roles, little is known about the role of class I homodimers. In this manuscript, we show that a linked dimer of Daughterless (Da), the only Drosophila class I bHLH protein, activates Atonal (Ato) expression and retinal neuron differentiation synergistically with the retinal determination factor Eyeless (Ey). The HLH protein Extramacrocheate (Emc), which forms heterodimer with Da, antagonizes the synergistic activation from Da but not the Da-Da linked dimer with Ey. We show that Da directly interacts with Ey and promotes Ey binding to the Ey binding site in the Ato 3׳ enhancer. Interestingly, the Ey binding site in the Ato 3׳ enhancer contains an embedded E-box that is also required for the synergistic activation by Ey and Da. Finally we show that mammalian homologs of Ey and Da can functionally replace their Drosophila counterparts to synergistically activate the Ato enhancer, suggesting that the observed function is evolutionary conserved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.