ArticleInternational journal of molecular sciences2014
Gamma knife treatment of brainstem metastases.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Stereotactic radiosurgery for the treatment of brainstem metastases: a multicenter retrospective study.Radiation oncology (London, England) · 2022Article
- The case for radiosurgery for brainstem metastases.Journal of neuro-oncology · 2019Article
- Adaptive hypofractionated gamma knife radiosurgery in the acute management of brainstem metastases.Surgical neurology international · 2019Article
- Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience.CNS oncology · 2018Article
- [Stereotactic radiosurgery for brainstem metastases : In experienced hands a good treatment option with excellent risk-benefit ratio].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017Article
- Stereotactic Radiosurgery for Brainstem Metastases: An International Cooperative Study to Define Response and Toxicity.International journal of radiation oncology, biology, physics · 2016Article
- Long-term Survival after Resection of HER2+ Infiltrating Ductal Carcinoma Metastasis to the Brainstem.Cureus · 2016Article
- Adaptive hypofractionated gamma knife radiosurgery for a large brainstem metastasis.Surgical neurology international · 2016Article
- Brainstem metastases treated with stereotactic radiosurgery: safety, efficacy, and dose response.Journal of neuro-oncology · 2015Article
- Stereotactic aspiration combined with gamma knife radiosurgery for the treatment of cystic brainstem metastasis originating from lung adenosquamous carcinoma: A case report.Oncology letters · 2015Article
- Brain metastases: an overview.CNS oncology · 2015Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of brainstem metastases is challenging. Surgical treatment is usually not an option, and chemotherapy is of limited utility. Stereotactic radiosurgery has emerged as a promising palliative treatment modality in these cases. The goal of this study is to assess our single institution experience treating brainstem metastases with Gamma Knife radiosurgery (GKRS). This retrospective chart review studied 41 patients with brainstem metastases treated with GKRS. The most common primary tumors were lung, breast, renal cell carcinoma, and melanoma. Median age at initial treatment was 59 years. Nineteen (46%) of the patients received whole brain radiation therapy (WBRT) prior to or concurrent with GKRS treatment. Thirty (73%) of the patients had a single brainstem metastasis. The average GKRS dose was 17 Gy. Post-GKRS overall survival at six months was 42%, at 12 months was 22%, and at 24 months was 13%. Local tumor control was achieved in 91% of patients, and there was one patient who had a fatal brain hemorrhage after treatment. Karnofsky performance score (KPS) >80 and the absence of prior WBRT were predictors for improved survival on multivariate analysis (HR 0.60 (p = 0.02), and HR 0.28 (p = 0.02), respectively). GKRS was an effective treatment for brainstem metastases, with excellent local tumor control.
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