Evidence map›Paper›PMID 24886736›Full record

ArticleThe journal of nutrition, health & aging2014

Long-term intake of nuts in relation to cognitive function in older women.

J O'Brien, O Okereke, E Devore, B Rosner, M Breteler, F Grodstein

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of nutrition, health & aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04075448 (The Acute Effect of a Walnut Intervention on Cognitive Performance , Brain Activation, and Serum Markers of Inflammation in Young Adults), which is not on this map. Cited by 57 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04075448 nacompletednot on this mapstarted 2019, after this paper: background citation

The Acute Effect of a Walnut Intervention on Cognitive Performance , Brain Activation, and Serum Markers of Inflammation in Young Adults

TypeinterventionalSponsorUniversity of ReadingRan2019 to 2020Enrolled32ConditionsCognitive Change, Mood, Inflammatory Response, Brain Derived Neurotrophic Factor LevelArmsControl, 50 g Walnut
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Nut Consumption for Cognitive Performance: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2021
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  12. Dietary habits and successful aging in Chinese older adults: a cross-sectional analysis of the CLHLS.Archives of public health = Archives belges de sante publique · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J O'BrienJacqueline O'Brien, Brigham and Women's Hospital, Channing Division of Network Medicine, 181 Longwood Avenue, Boston MA 02115, Phone: 617-240-0097, Fax: 617-525-4597, Email: jlo391@mail.harvard.edu.
O Okereke
E Devore
B Rosner
M Breteler
F Grodstein

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
TRAINING PROGRAM IN EPIDEMIOLOGIC RESEARCH ON AGINGT32AG000158 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 1988 to 2015
$2.1M
Dietary Fat Composition, Plasma Lipids, and Cognitive DeclineK08AG029813 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI OKEREKE, OLIVIA IFEOMA · 2008 to 2011
$531k
NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA87969NIA NIH HHS K08 AG029813NIA NIH HHS T32 AG000158NIA NIH HHS T32-AG000158PHS HHS K08029813
6 · The paper itself

Abstract

objectiveNuts contain nutrients that may benefit brain health; thus, we examined long-term intake of nuts in relation to cognition in older women.

designPopulation-based prospective cohort study.

settingAcademic research using data from the Nurses' Health Study.

participantsNut intake was assessed in a food-frequency questionnaire beginning in1980, and approximately every four years thereafter. Between 1995-2001, 16,010 women age 70 or older (mean age = 74 years) without a history of stroke were administered 4 repeated telephone-based cognitive interviews over 6 years. Our final sample included 15,467 women who completed an initial cognitive interview and had complete information on nut intake.

main outcome measuresThe Telephone Interview for Cognitive Status (TICS), a global score averaging the results of all tests (TICS, immediate and delayed verbal recall, category fluency, and attention), and a verbal memory score averaging the results of tests of verbal recall.

resultsIn multivariable-adjusted linear regression models, higher long-term total nut intake was associated with better average cognitive status for all cognitive outcomes. For the global composite score combining all tests, women consuming at least 5 servings of nuts/week had higher scores than non-consumers (mean difference=0.08 standard units, 95% confidence interval 0.00-0.15; p-trend=0.003). This mean difference of 0.08 is equivalent to the mean difference we find between women 2 years apart in age. Long-term intake of nuts was not associated with rates of cognitive decline.

conclusionsHigher nut intake may be related to better overall cognition at older ages, and could be an easily-modifiable public health intervention.

Indexed as

NutsAgedAttentionCognitionCognition DisordersCohort StudiesDietEatingFemaleHealth SurveysHumansMental RecallNursesProspective StudiesTime Factors

Identifiers

PMID24886736
PMCPMC4105147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.