Evidence map›Paper›PMID 24886715›Full record

Trial reportPloS one2014

Reproducibility of Fatmax and fat oxidation rates during exercise in recreationally trained males.

Ilaria Croci, Fabio Borrani, Nuala M Byrne, Nuala Byrne, Rachel E Wood, Rachel Wood, Ingrid J Hickman, Ingrid Hickman, Xavier Chenevière, Davide Malatesta

Erratum issuedAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Divergent Changes in Peak Fat Oxidation and FatScandinavian journal of medicine & science in sports · 2025
    Trial
  5. Trial
  6. Trial
  7. The day-to-day reliability of peak fat oxidation and FATEuropean journal of applied physiology · 2020
    Trial
  8. Trial
  9. Exercise and Fat: A Primer.Sports medicine - open · 2026
    Review
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Maximal Fat Oxidation during Incremental Upper and Lower Body Exercise in Healthy Young Males.International journal of environmental research and public health · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
    Byrne, Nuala [corrected to Byrne, Nuala M]; Wood, Rachel [corrected to Wood, Rachel E]; Hickman, Ingrid [corrected to Hickman, Ingrid J]
5 · Who and what money

Authors and funding

10 authors.

Ilaria CrociThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Australia; School of Human Movement Studies, University of Queensland, Brisbane, Australia.
Fabio BorraniInstitute of Sport Sciences University of Lausanne, University of Lausanne, Lausanne, Switzerland; Department of Physiology, University of Lausanne, Lausanne, Switzerland.
Nuala M Byrne
Nuala ByrneInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia; Bond Institute of Health and Sport, Bond University, Robina, Australia.
Rachel E Wood
Rachel WoodInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Ingrid J Hickman
Ingrid HickmanThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Australia; Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Australia; Mater Medical Research Institute, Mater Mother's Hospital, Brisbane, Australia.
Xavier ChenevièreInstitute of Sport Sciences University of Lausanne, University of Lausanne, Lausanne, Switzerland; Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Davide MalatestaInstitute of Sport Sciences University of Lausanne, University of Lausanne, Lausanne, Switzerland; Department of Physiology, University of Lausanne, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aerobic exercise training performed at the intensity eliciting maximal fat oxidation (Fat(max)) has been shown to improve the metabolic profile of obese patients. However, limited information is available on the reproducibility of Fat(max) and related physiological measures. The aim of this study was to assess the intra-individual variability of: a) Fat(max) measurements determined using three different data analysis approaches and b) fat and carbohydrate oxidation rates at rest and at each stage of an individualized graded test. Fifteen healthy males [body mass index 23.1 ± 0.6 kg/m(2), maximal oxygen consumption (VO2max) 52.0 ± 2.0 ml/kg/min] completed a maximal test and two identical submaximal incremental tests on ergocycle (30-min rest followed by 5-min stages with increments of 7.5% of the maximal power output). Fat and carbohydrate oxidation rates were determined using indirect calorimetry. Fat(max) was determined with three approaches: the sine model (SIN), measured values (MV) and 3rd polynomial curve (P3). Intra-individual coefficients of variation (CVs) and limits of agreement were calculated. CV for Fat(max) determined with SIN was 16.4% and tended to be lower than with P3 and MV (18.6% and 20.8%, respectively). Limits of agreement for Fat(max) were -2 ± 27% of VO2max with SIN, -4 ± 32 with P3 and -4 ± 28 with MV. CVs of oxygen uptake, carbon dioxide production and respiratory exchange rate were <10% at rest and <5% during exercise. Conversely, CVs of fat oxidation rates (20% at rest and 24-49% during exercise) and carbohydrate oxidation rates (33.5% at rest, 8.5-12.9% during exercise) were higher. The intra-individual variability of Fat(max) and fat oxidation rates was high (CV>15%), regardless of the data analysis approach employed. Further research on the determinants of the variability of Fat(max) and fat oxidation rates is required.

Indexed as

ExerciseLipid MetabolismRecreationAdultCarbon DioxideHumansMaleModels, BiologicalOxidation-ReductionOxygen ConsumptionReproducibility of ResultsRespirationCarbon Dioxide

Identifiers

PMID24886715
PMCPMC4041727

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.