Trial reportHealth and quality of life outcomes2014
Could baseline health-related quality of life (QoL) predict overall survival in metastatic colorectal cancer? The results of the GERCOR OPTIMOX 1 study.
Trial report in Health and quality of life outcomes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02844608 (Quality of Life Assessment in Routine Clinical Oncology Practice at the University Hospital of Besancon), which is not on this map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quality of Life Assessment in Routine Clinical Oncology Practice at the University Hospital of Besancon
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Patient-Reported Outcomes as Prognostic Indicators for Overall Survival in Cancer: A Systematic Review and Meta-Analysis.JAMA oncology · 2025Pooled it
- Patient-reported outcomes as predictors of survival in patients with bowel cancer: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Pooled it
- Personalizing prognosis in colorectal cancer: A systematic review of the quality and nature of clinical prognostic tools for survival outcomes.Journal of surgical oncology · 2017Pooled it
- A systematic review of the impact of pain on overall survival in patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Pooled it
- The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis.BMC cancer · 2016Pooled it
- Patient-reported symptom burden as a prognostic factor in treatment with first-line cetuximab plus chemotherapy for unresectable metastatic colorectal cancer: Results of Phase II QUACK trial.Cancer medicine · 2020Trial
- Prognostic nomogram and score to predict overall survival in locally advanced untreated pancreatic cancer (PROLAP).British journal of cancer · 2016Trial
- Observational
- Health-related quality of life is a significant prognostic factor for recurrence and overall survival in patients with colon cancer.BMC cancer · 2025Observational
- The role of health-related quality of life in improving cancer outcomes.Journal of clinical and translational research · 2023Article
- Replacing performance status with a simple patient-reported outcome in palliative radiotherapy prognostic modelling.Clinical and translational radiation oncology · 2022Article
- Methodological Investigation of Time Perspective Scoring and Quality of Life among Individuals with Multiple Sclerosis.International journal of environmental research and public health · 2022Article
- Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Development and validation of a novel prognostic score to predict survival in patients with metastatic colorectal cancer: the metastatic colorectal cancer score (mCCS).Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2019Article
- A single question regarding mobility in the World Health Organization quality of life questionnaire predicts 3-year mortality in patients receiving chronic hemodialysis.Scientific reports · 2017Article
- Improving Outcomes in Patients with CRC: The Role of Patient Reported Outcomes-An ESDO Report.Cancers · 2017Review
- Quality of Life and Mortality of Long-Term Colorectal Cancer Survivors in the Seattle Colorectal Cancer Family Registry.PloS one · 2016Article
- Colorectal cancer.Nature reviews. Disease primers · 2015Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHealth-related quality of life (QoL) has prognostic value in many cancers. A recent study found that the performance of prognostic systems for metastatic colorectal cancer (mCRC) were improvable. We evaluated the independent prognostic value of QoL for overall survival (OS) and its ability to improve two prognostic systems'performance (Köhne and GERCOR models) for patients with mCRC.
methodsThe EQ-5D questionnaire was self-completed before randomization in the OPTIMOX1, a phase III trial comparing two strategies of FOLFOX chemotherapy which included 620 previously untreated mCRC patients recruited from January 2000 to June 2002 from 56 institutions in five countries. The improvement in models' performance (after addition of QoL) was studied with Harrell's C-index and the net reclassification improvement.
resultsOf the 620 patients, 249 (40%) completed QoL datasets. The Köhne model could be improved by LDH, mobility and pain/discomfort; the C-index rose from 0.54 to 0.67. The associated NRI for 12-month death was 0.23 [0.05; 0.46]. Mobility and pain/discomfort could be added to the GERCOR model: the C-index varied from 0.63 to 0.68. The NRI for 12 months death was 0.35 [0.12; 0.44].
conclusionsMobility and pain dimensions of EQ5D are independent prognostic factors and could be useful for staging and treatment assignment of mCRC patients. Presented at the 2011 ASCO Annual Meeting (#3632).
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