ArticleBiomedical engineering online2014
An inverse method to determine the mechanical properties of the iris in vivo.
Article in Biomedical engineering online, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Experimental Assessment of Iris Water Content and Sex Differences in Mature Rabbits.bioRxiv : the preprint server for biology · 2026Article
- Relationship between acceleration of axial elongation and ocular biometry in schoolchildren.Japanese journal of ophthalmology · 2025Observational
- Article
- The Structural Layers of the Porcine Iris Exhibit Inherently Different Biomechanical Properties.Investigative ophthalmology & visual science · 2023Article
- An Inverse Method to Determine Mechanical Parameters of Porcine Vitreous Bodies Based on the Indentation Test.Bioengineering (Basel, Switzerland) · 2023Article
- Experimental evaluation of the viscoelasticity of porcine vitreous.Journal of the Royal Society, Interface · 2021Article
- In vivo estimation of murine iris stiffness using finite element modeling.Experimental eye research · 2021Article
- Sex Differences in Rate of Axial Elongation and Ocular Biometrics in Elementary School Students.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Computational Study on the Biomechanics of Pupil Block Phenomenon.BioMed research international · 2019Article
- Numerical stress analysis of the iris tissue induced by pupil expansion: Comparison of commercial devices.PloS one · 2018Article
- Estimating Human Trabecular Meshwork Stiffness by Numerical Modeling and Advanced OCT Imaging.Investigative ophthalmology & visual science · 2017Article
- Biomechanics of the sclera and effects on intraocular pressure.International journal of ophthalmology · 2016Review
- Customized Finite Element Modelling of the Human Cornea.PloS one · 2015Article
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4 authors.
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Abstract
backgroundUnderstanding the mechanical properties of the iris can help to have an insight into the eye diseases with abnormalities of the iris morphology. Material parameters of the iris were simply calculated relying on the ex vivo experiment. However, the mechanical response of the iris in vivo is different from that ex vivo, therefore, a method was put forward to determine the material parameters of the iris using the optimization method in combination with the finite element method based on the in vivo experiment. MATERIAL AND
methodsOcular hypertension was induced by rapid perfusion to the anterior chamber, during perfusion intraocular pressures in the anterior and posterior chamber were record by sensors, images of the anterior segment were captured by the ultrasonic system. The displacement of the characteristic points on the surface of the iris was calculated. A finite element model of the anterior chamber was developed using the ultrasonic image before perfusion, the multi-island genetic algorithm was employed to determine the material parameters of the iris by minimizing the difference between the finite element simulation and the experimental measurements.
resultsMaterial parameters of the iris in vivo were identified as the iris was taken as a nearly incompressible second-order Ogden solid. Values of the parameters μ1, α1, μ2 and α2 were 0.0861 ± 0.0080 MPa, 54.2546 ± 12.7180, 0.0754 ± 0.0200 MPa, and 48.0716 ± 15.7796 respectively. The stability of the inverse finite element method was verified, the sensitivity of the model parameters was investigated.
conclusionMaterial properties of the iris in vivo could be determined using the multi-island genetic algorithm coupled with the finite element method based on the experiment.
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