SynthesisBMC musculoskeletal disorders2014
Stem cell therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review.
Synthesis in BMC musculoskeletal disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- The pandemic is gone but its consequences are here to stay: avascular necrosis following corticosteroids administration for severe COVID-19.Journal of orthopaedic surgery and research · 2024Pooled it
- Hip survival rate in the patients with avascular necrosis of femoral head after transtrochanteric rotational osteotomy: a systematic review and meta-analysis.Chinese medical journal · 2019Pooled it
- [Update of the German S3 guideline on atraumatic femoral head necrosis in adults].Der Orthopade · 2018Guideline
- Regenerative therapies increase survivorship of avascular necrosis of the femoral head: a systematic review and meta-analysis.International orthopaedics · 2018Pooled it
- Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis.BioMed research international · 2017Pooled it
- Clinical outcomes of osteonecrosis of the femoral head after autologous bone marrow stem cell implantation: a meta-analysis of seven case-control studies.Clinics (Sao Paulo, Brazil) · 2016Pooled it
- Article
- Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral head.Biomedical journal · 2023Article
- MicroRNA‑141 inhibits the differentiation of bone marrow‑derived mesenchymal stem cells in steroid‑induced osteonecrosis via E2F3.Molecular medicine reports · 2022Article
- Cell therapy for osteonecrosis of femoral head and joint preservation.Journal of clinical orthopaedics and trauma · 2022Article
- The therapeutic effect of adipose-derived lipoaspirate cells in femoral head necrosis by improving angiogenesis.Frontiers in cell and developmental biology · 2022Article
- Autologous stem cell implantation with core decompression for avascular necrosis of the femoral head using a new device.Annals of the Royal College of Surgeons of England · 2021Article
- Comparison of cell therapy and other novel adjunctive therapies combined with core decompression for the treatment of osteonecrosis of the femoral head : a systematic review and meta-analysis of 20 studies.Bone & joint research · 2021Article
- ARG2, MAP4K5 and TSTA3 as Diagnostic Markers of Steroid-Induced Osteonecrosis of the Femoral Head and Their Correlation With Immune Infiltration.Frontiers in genetics · 2021Article
- Recombinant Human Bone Morphogenic Protein-2 Immobilized Fabrication of Magnesium Functionalized Injectable Hydrogels for Controlled-Delivery and Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells in Femoral Head Necrosis Repair.Frontiers in cell and developmental biology · 2021Article
- Porous tantalum rod implantation is associated with low survival rates in patients with type C2 osteonecrosis of the femoral head but has no effect on the clinical outcome of conversion total hip arthroplasty: a retrospective study with an average 8-year follow-up.BMC musculoskeletal disorders · 2020Article
- Isolation and characterization of mesenchymal stem cells in orthopaedics and the emergence of compact bone mesenchymal stem cells as a promising surgical adjunct.World journal of stem cells · 2020Review
- Mesenchymal stromal cells for osteonecrosis.Journal of translational medicine · 2020Review
- Efficacy of orthobiologic adjuvants to core decompression for hip preservation in avascular necrosis hip.Journal of hip preservation surgery · 2020Review
- Correlational analysis between neutrophil granulocyte levels and osteonecrosis of the femoral head.BMC musculoskeletal disorders · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAvascular necrosis (AVN) of the femoral head (FH) is believed to be caused by a multitude of etiologic factors and is associated with significant morbidity in younger populations. Eventually, the disease progresses and results in FH collapse. Thus, a focus on early disease management aimed at joint preservation by preventing or delaying progression is key. The use of stem cells (SC) for the treatment of AVN of the FH has been proposed. We undertook a systematic review of the medical literature examining the use of SC for the treatment of early stage (precollapse) AVN of the FH, in both pre-clinical and clinical studies.
methodsData collected included: Pre-clinical studies - model of AVN, variety and dosage of SC, histologic and imaging analyses. Clinical studies - study design, classification and etiology of AVN, SC dosage and treatment protocol, incidence of disease progression, patient reported outcomes, volume of necrotic lesion and hip survivorship.
resultsIn pre-clinical studies, the use of SC uniformly demonstrated improvements in osteogenesis and angiogenesis, yet source of implanted SC was variable. In clinical studies, groups treated with SC showed significant improvements in patient reported outcomes; however hip survivorship was not affected. Discrepancies regarding dose of SC, AVN etiology and disease severity were present.
conclusionsRoutine use of this treatment method will first require further research into dose and quality optimization as well as confirmed improvements in hip survivorship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.