ArticleBMC biology2014
A wide range of pheromone-stimulated sexual and reproductive behaviors in female mice depend on G protein Gαo.
Article in BMC biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- Article
- Neural control of female sexual behaviors.Hormones and behavior · 2023Review
- Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice.iScience · 2023Article
- Article
- Behavioral evidence of the functional interaction between the main and accessory olfactory system suggests a large olfactory system with a high plastic capability.Frontiers in neuroanatomy · 2023Review
- Lifespan extension in female mice by early, transient exposure to adult female olfactory cues.eLife · 2022Article
- Article
- Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents.Development (Cambridge, England) · 2022Article
- Mechanisms underlying pre- and postnatal development of the vomeronasal organ.Cellular and molecular life sciences : CMLS · 2021Review
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Sensory Detection by the Vomeronasal Organ Modulates Experience-Dependent Social Behaviors in Female Mice.Frontiers in cellular neuroscience · 2021Article
- Inhibitory signaling in mammalian olfactory transduction potentially mediated by GαMolecular and cellular neurosciences · 2021Article
- Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Central role of G protein Gαi2 and Gαi2Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Conditional Deletion ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Dichotomous Distribution of Putative Cholinergic Interneurons in Mouse Accessory Olfactory Bulb.Frontiers in neuroanatomy · 2017Article
- Activity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory Bulb at Puberty.Frontiers in neuroanatomy · 2017Article
- Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- State-dependent responses to sex pheromones in mouse.Current opinion in neurobiology · 2016Review
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8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundOptimal reproductive fitness is essential for the biological success and survival of species. The vomeronasal organ is strongly implicated in the display of sexual and reproductive behaviors in female mice, yet the roles that apical and basal vomeronasal neuron populations play in controlling these gender-specific behaviors remain largely unclear.
resultsTo dissect the neural pathways underlying these functions, we genetically inactivated the basal vomeronasal organ layer using conditional, cell-specific ablation of the G protein Gαo. Female mice mutant for Gαo show severe alterations in sexual and reproductive behaviors, timing of puberty onset, and estrous cycle. These mutant mice are insensitive to reproductive facilitation stimulated by male pheromones that accelerate puberty and induce ovulation. Gαo-mutant females exhibit a striking reduction in sexual receptivity or lordosis behavior to males, but gender discrimination seems to be intact. These mice also show a loss in male scent preference, which requires a learned association for volatile olfactory signals with other nonvolatile ownership signals that are contained in the high molecular weight fraction of male urine. Thus, Gαo impacts on both instinctive and learned social responses to pheromones.
conclusionsThese results highlight that sensory neurons of the Gαo-expressing vomeronasal subsystem, together with the receptors they express and the molecular cues they detect, control a wide range of fundamental mating and reproductive behaviors in female mice.
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