ArticleGenome biology2014
SoxNeuro orchestrates central nervous system specification and differentiation in Drosophila and is only partially redundant with Dichaete.
Article in Genome biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 39 citations in OpenAlex.
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- Single-cell transcriptomics of theProceedings of the National Academy of Sciences of the United States of America · 2026Article
- A Subset of Circulating Hemocytes Expresses Genes Indicating Neural Precursor Identity.Cellular and molecular neurobiology · 2026Article
- Genome-wide identification, evolutionary diversification and developmental expression of the Sox gene family in three brachyuran crabs.BMC genomics · 2026Article
- Early nervous system development in the chaetognathFrontiers in cell and developmental biology · 2026Article
- Concurrent temporal patterning of neural stem cells in the fly visual system.Nature communications · 2025Article
- Coordinated control of neuronal differentiation and wiring by sustained transcription factors.Science (New York, N.Y.) · 2022Article
- Cephalopod retinal development shows vertebrate-like mechanisms of neurogenesis.Current biology : CB · 2022Article
- Homologous gene regulatory networks control development of apical organs and brains in Bilateria.Science advances · 2022Article
- Gene Regulatory Networks of Epidermal and Neural Fate Choice in a Chordate.Molecular biology and evolution · 2022Article
- A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing.Nature communications · 2022Article
- The Role of microRNAs in theFrontiers in cell and developmental biology · 2022Review
- Yamanaka Factors in the Budding TunicateFrontiers in cell and developmental biology · 2022Article
- Article
- Investigating cellular and molecular mechanisms of neurogenesis in Capitella teleta sheds light on the ancestor of Annelida.BMC evolutionary biology · 2020Article
- Transcriptional control of morphological properties of direction-selective T4/T5 neurons inDevelopment (Cambridge, England) · 2019Article
- Duplication and expression of Sox genes in spiders.BMC evolutionary biology · 2018Article
- Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster.PLoS genetics · 2018Article
- Embryonic expression patterns and phylogenetic analysis of panarthropod sox genes: insight into nervous system development, segmentation and gonadogenesis.BMC evolutionary biology · 2018Article
- FlyExpress 7: An Integrated Discovery Platform To Study Coexpressed Genes UsingG3 (Bethesda, Md.) · 2017Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundSox proteins encompass an evolutionarily conserved family of transcription factors with critical roles in animal development and stem cell biology. In common with vertebrates, the Drosophila group B proteins SoxNeuro and Dichaete are involved in central nervous system development, where they play both similar and unique roles in gene regulation. Sox genes show extensive functional redundancy across metazoans, but the molecular basis underpinning functional compensation mechanisms at the genomic level are currently unknown.
resultsUsing a combination of genome-wide binding analysis and gene expression profiling, we show that SoxNeuro directs embryonic neural development from the early specification of neuroblasts through to the terminal differentiation of neurons and glia. To address the issue of functional redundancy and compensation at a genomic level, we compare SoxNeuro and Dichaete binding, identifying common and independent binding events in wild-type conditions, as well as instances of compensation and loss of binding in mutant backgrounds.
conclusionsWe find that early aspects of group B Sox functions in the central nervous system, such as stem cell maintenance and dorsoventral patterning, are highly conserved. However, in contrast to vertebrates, we find that Drosophila group B1 proteins also play prominent roles during later aspects of neural morphogenesis. Our analysis of the functional relationship between SoxNeuro and Dichaete uncovers evidence for redundant and independent functions for each protein, along with unexpected examples of compensation and interdependency, thus providing new insights into the general issue of transcription factor functional redundancy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.