ArticleParasites & vectors2014
Anti-feeding efficacy of Activyl® Tick Plus topical treatment of dogs against Phlebotomus perniciosus.
Article in Parasites & vectors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTopical permethrin treatment is known to prevent feeding of sandflies on dogs. This study investigated the anti-feeding efficacy and the immediate insecticidal efficacy (knock-down effect) of topical treatment of dogs with a new commercially available combination of indoxacarb and permethrin (Activyl® Tick Plus), compared with a negative control.
methodsSedated dogs were individually exposed to unfed female sandflies in a darkened chamber for one hour 2, 7, 14, 21 and 29 days after treatment. Mean fly feeding and survival rates in the two groups after one hour of exposure were used to calculate the anti-feeding efficacy and the knock-down effect, respectively.
resultsOn Days 2, 7, 14, 21 and 29 post treatment, the anti-feeding efficacy was 99, 98, 96, 88 and 84% based on geometric means. The mean number of fed sandflies in the treated group was significantly lower than in the control group mean at every evaluation time point. The knock-down effect, measured at one hour after exposure of the flies to treated dogs, was 32, 27, 9, 0 and 4% based on geometric means, at the same time points. The number of dead flies was significantly higher in the treated group on Days 2 and 7 post-treatment. No adverse effects of treatment were observed at any time during the study.
conclusionsActivyl® Tick Plus treatment of dogs provided a high anti-feeding efficacy against Phlebotomus perniciosus from 2 to 21 days post treatment, with continuing significant anti-feeding to 29 days post-treatment, and was well tolerated. Some knock-down effect following one hour of exposure of flies to treated dogs was observed in the first week after treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.