ArticleBMC genomics2014
A new association test based on disease allele selection for case-control genome-wide association studies.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- A gene-based test of association through an orthogonal decomposition of genotype scores.Human genetics · 2017Article
- A new statistical approach to combining p-values using gamma distribution and its application to genome-wide association study.BMC bioinformatics · 2014Article
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Authors and funding
1 author.
Funding
Abstract
backgroundCurrent robust association tests for case-control genome-wide association study (GWAS) data are mainly based on the assumption of some specific genetic models. Due to the richness of the genetic models, this assumption may not be appropriate. Therefore, robust but powerful association approaches are desirable.
resultsIn this paper, we propose a new approach to testing for the association between the genotype and phenotype for case-control GWAS. This method assumes a generalized genetic model and is based on the selected disease allele to obtain a p-value from the more powerful one-sided test. Through a comprehensive simulation study we assess the performance of the new test by comparing it with existing methods. Some real data applications are also used to illustrate the use of the proposed test.
conclusionsBased on the simulation results and real data application, the proposed test is powerful and robust.
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