ArticleMolecular brain2014
Extrasynaptic GABAA receptors in mediodorsal thalamic nucleus modulate fear extinction learning.
Article in Molecular brain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
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- Using in vivo MRI to reveal circuits that are sensitive to traumatic stress in male and female rats.Neuropharmacology · 2025Article
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- Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans.bioRxiv : the preprint server for biology · 2025Article
- Unveiling the Mystery of the Stimulatory Effects of Arecoline: Its Relevance to the Regulation of Neurotransmitters and the Microecosystem in Multi-Ecological Intestinal Sites.International journal of molecular sciences · 2025Article
- Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction.Molecular brain · 2025Article
- GABA tone regulation and its cognitive functions in the brain.Nature reviews. Neuroscience · 2023Review
- The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice.Nature communications · 2023Article
- Cerebellar control of fear learning via the cerebellar nuclei-Multiple pathways, multiple mechanisms?Frontiers in systems neuroscience · 2023Review
- Gray Matter Volume of Thalamic Nuclei in Traumatized North Korean Refugees.Frontiers in psychiatry · 2022Article
- The Role of the Thalamus in Post-Traumatic Stress Disorder.International journal of molecular sciences · 2021Review
- Multimodal MRI Assessment of Thalamic Structural Changes in Earthquake Survivors.Diagnostics (Basel, Switzerland) · 2021Article
- The Contribution of Thalamic Nuclei in Salience Processing.Frontiers in behavioral neuroscience · 2021Review
- Nucleus reuniens mediates the extinction of contextual fear conditioning.Behavioural brain research · 2019Article
- An Emerging Circuit Pharmacology of GABATrends in pharmacological sciences · 2018Review
- Ulk4 regulates GABAergic signaling and anxiety-related behavior.Translational psychiatry · 2018Article
- Palmitoylation as a Functional Regulator of Neurotransmitter Receptors.Neural plasticity · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe gamma-amino-butyric acid (GABA) system is a critical mediator of fear extinction process. GABA can induce "phasic" or "tonic" inhibition in neurons through synaptic or extrasynaptic GABAA receptors, respectively. However, role of the thalamic "tonic GABA inhibition" in cognition has not been explored. We addressed this issue in extinction of conditioned fear in mice.
resultsHere, we show that GABAA receptors in the mediodorsal thalamic nucleus (MD) modulate fear extinction. Microinjection of gabazine, a GABAA receptor antagonist, into the MD decreased freezing behavior in response to the conditioned stimulus and thus facilitated fear extinction. Interestingly, microinjection of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol), a preferential agonist for the δ-subunit of extrasynaptic GABAA receptors, into the MD attenuated fear extinction. In the opposite direction, an MD-specific knock-out of the extrasynaptic GABAA receptors facilitated fear extinction.
conclusionsOur results suggest that "tonic GABA inhibition" mediated by extrasynaptic GABAA receptors in MD neurons, suppresses fear extinction learning. These results raise a possibility that pharmacological control of tonic mode of GABAA receptor activation may be a target for treatment of anxiety disorders like post-traumatic stress disorder.
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