ArticleBMC genomics2014
Genomic analysis of the emergence of 20th century epidemic dysentery.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- The changing epidemiology of shigellosis in Australia, 2001-2019.PLoS neglected tropical diseases · 2023Article
- Evaluation of in vitro and in vivo antibiotic efficacy against a novel bioluminescent Shigella flexneri.Scientific reports · 2019Article
- Looking Backward To Move Forward: the Utility of Sequencing Historical Bacterial Genomes.Journal of clinical microbiology · 2019Review
- Mutational convergence acts as a major player in adaptive parallel evolution of Shigella spp.Scientific reports · 2019Article
- Forensic Approaches to Detect Possible Agents of Bioterror.Microbiology spectrum · 2017Review
- How Do the Virulence Factors ofFrontiers in cellular and infection microbiology · 2017Review
- Article
- The genomic signatures of Shigella evolution, adaptation and geographical spread.Nature reviews. Microbiology · 2016Review
- Global phylogeography and evolutionary history of Shigella dysenteriae type 1.Nature microbiology · 2016Article
- Introduction and establishment of fluoroquinolone-resistantMicrobial genomics · 2015Article
- Article
- Phylogenetic Analyses of Shigella and Enteroinvasive Escherichia coli for the Identification of Molecular Epidemiological Markers: Whole-Genome Comparative Analysis Does Not Support Distinct Genera Designation.Frontiers in microbiology · 2015Article
- Genome sequencing, annotation and comparative genomic analysis of Shigella dysenteriae strain SD1D.Gut pathogens · 2014Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundShigella dysenteriae type 1 (Sd1) causes recurrent epidemics of dysentery associated with high mortality in many regions of the world. Sd1 infects humans at very low infectious doses (10 CFU), and treatment is complicated by the rapid emergence of antibiotic resistant Sd1 strains. Sd1 is only detected in the context of human infections, and the circumstances under which epidemics emerge and regress remain unknown.
resultsPhylogenomic analyses of 56 isolates collected worldwide over the past 60 years indicate that the Sd1 clone responsible for the recent pandemics emerged at the turn of the 20th century, and that the two world wars likely played a pivotal role for its dissemination. Several lineages remain ubiquitous and their phylogeny indicates several recent intercontinental transfers. Our comparative genomics analysis reveals that isolates responsible for separate outbreaks, though closely related to one another, have independently accumulated antibiotic resistance genes, suggesting that there is little or no selection to retain these genes in-between outbreaks. The genomes appear to be subjected to genetic drift that affects a number of functions currently used by diagnostic tools to identify Sd1, which could lead to the potential failure of such tools.
conclusionsTaken together, the Sd1 population structure and pattern of evolution suggest a recent emergence and a possible human carrier state that could play an important role in the epidemic pattern of infections of this human-specific pathogen. This analysis highlights the important role of whole-genome sequencing in studying pathogens for which epidemiological or laboratory investigations are particularly challenging.
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