ArticleBMC infectious diseases2014
Epidemic and virulence characteristic of Shigella spp. with extended-spectrum cephalosporin resistance in Xiaoshan District, Hangzhou, China.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- The increasing antimicrobial resistance ofPathogens and global health · 2023Pooled it
- Guidelines for the treatment of dysentery (shigellosis): a systematic review of the evidence.Paediatrics and international child health · 2018Pooled it
- Identification of a novel mutation of sat (Gly82Arg) in Shigella flexneri serotype 7a: insights into clinical relevance.Folia microbiologica · 2026Article
- Extended spectrum β-lactamase and integron genes among Shigella flexneri and Shigella sonnei isolated from children with diarrhea in shiraz, Southwest Iran.BMC pediatrics · 2025Article
- Molecular characterization of extended-spectrum cephalosporin and fluoroquinolone resistance genes inHeliyon · 2022Article
- Prevalence of Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2022Review
- Characterization of multi-resistant Shigella species isolated from raw cow milk and milk products.The Journal of veterinary medical science · 2022Article
- Diarrhea in an infant due to Shigella flexneri 1 carrying multiple cephalosporinase-encoding genes.Gut pathogens · 2021Article
- Epidemic and molecular characterization of fluoroquinolone-resistant Shigella dysenteriae 1 isolates from calves with diarrhea.BMC microbiology · 2021Article
- Shigella sonnei: virulence and antibiotic resistance.Archives of microbiology · 2021Review
- Shigella flexneri: an emerging pathogen.Folia microbiologica · 2020Review
- High Rates of Antimicrobial Resistance and Virulence Gene Distribution AmongInfection and drug resistance · 2020Article
- Prevalence of Plasmid-Mediated Determinants With Decreased Susceptibility to Azithromycin AmongFrontiers in microbiology · 2020Article
- Article
- Molecular characterization of fluoroquinolone and/or cephalosporin resistance in Shigella sonnei isolates from yaks.BMC veterinary research · 2018Article
- Dominant serotype distribution and antimicrobial resistance profile of Shigella spp. in Xinjiang, China.PloS one · 2018Article
- Article
- Profiling of Virulence-associated Factors inOsong public health and research perspectives · 2017Article
- Genome sequence of Shigella flexneri strain SP1, a diarrheal isolate that encodes an extended-spectrum β-lactamase (ESBL).Annals of clinical microbiology and antimicrobials · 2017Article
- Prospective study on the overuse of blood test-guided antibiotics on patients with acute diarrhea in primary hospitals of China.Patient preference and adherence · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundShigellae have become increasingly resistant to the extended-spectrum cephalosporin (ESC) worldwide and pose a great challenge to anti-infection treatment options. The purpose of this study was to determine the resistance, cephalosporin resistance mechanisms, virulence characteristic and genotype of ESC-resistant Shigella.
methodsFrom 2008 to 2012, Shigella isolates collected from diarrhea patients were detected for antibiotics sensitivity by disk diffusion, cephalosporin resistance determinants and virulence genes using polymerase chain reaction (PCR) and genotyping through enterobacterial repetitive intergenic consensus sequence PCR (ERIC-PCR).
resultsA total of 356 Shigella isolates were gathered, and 198 (55.6%, 58 S. flexneri and 140 S. sonnei) were resistant to ESC. All ESC-resistant isolates were susceptible to imipenem, and only 0.5% isolate was resistant to piperacillin/tazobactam. ESC-resistant S. flexneri showed high degrees of resistance to ampicillin (100%), ampicillin/sulbactam (96.6%), piperacillin (100%), trimethoprim/sulfamethoxazole (74.1%), ciprofloxacin (74.1%), levofloxacin (53.4%), ceftazidime (58.6%) and cefepime (58.6%). ESC-resistant S. sonnei exhibited high resistance rates to ampicillin (100%), piperacillin (100%) and trimethoprim/sulfamethoxazole (96.4%). Cephalosporin resistance genes were confirmed in 184 ESC-resistant isolates. bla(CTX-M) types (91.8%, mainly bla(CTX-M-14), bla(CTX-M-15) and bla(CTX-M-57)) were most prevalent, followed by bla(OXA-30) (26.3%). Over 99.0% ESC-resistant isolates harbored virulence genes ial, ipaH, virA and sen. However, set1 were more prevalent in ESC-resistant S. flexneri isolates than in S. sonnei isolates. ERIC-PCR results showed that 2 and 3 main genotypes were detected in ESC-resistant S. flexneri and S. sonnei, respectively.
conclusionOur findings indicated that a high prevalence of ESC-resistant Shigella mediated mainly by bla(CTX-M) with stronger resistance and virulence, and the existence of specific clones responsible for these Shigella infection in the region studied.
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