ArticleBMC public health2014
Association between hepatitis B virus infection and metabolic syndrome: a retrospective cohort study in Shanghai, China.
Article in BMC public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Associations of Chronic Hepatitis B and Nonalcoholic Fatty Liver Diseases with New-Onset Metabolic Syndrome in Military Personnel before Midlife: A Cohort Study.Endocrine, metabolic & immune disorders drug targets · 2025Article
- Prevalence of Non-Alcoholic Fatty Liver Disease and Its Impact on Fibrosis Risk in Inactive Chronic Hepatitis B Patients: Insights from a Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Hepatitis B virus infection and the risk of gynecologic cancers: a systematic review and meta-analysis.Discover oncology · 2024Article
- Chronic hepatitis B-associated liver disease in the context of human immunodeficiency virus co-infection and underlying metabolic syndrome.World journal of virology · 2020Review
- Association between chronic hepatitis B infection and metabolic syndrome.Journal of diabetes and metabolic disorders · 2018Article
- Obesity paradox, obesity orthodox, and the metabolic syndrome: An approach to unity.Molecular medicine (Cambridge, Mass.) · 2017Article
- Association between hepatitis B and metabolic syndrome: Current state of the art.World journal of gastroenterology · 2016Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolic syndrome (MS) and hepatitis B (HBV) infection are two major public health problems in China. There are few studies about their association, and the results of these studies are contradictory. We conducted a retrospective cohort study to assess the association between MS and HBV in a Shanghai community-based cohort.
methodsNine hundred seventy-six Shanghai residents were recruited from the Putuo community. 480 HBV infections were in exposed group and 496 non-infections in unexposed group. All metabolic-related parameters and hepatitis B serology were tested with routine biochemical or immunological methods. "Exposed" was defined by HBV infection represented by hepatitis B surface antigen (HBsAg) and without anti-virus treatment. "Unexposed" were subjects who didn't infect with HBV (Represented by HBsAg) and no MS when they entered the cohort. MS was defined based on the updated National Cholesterol Education Program Adult Treatment Panel III criteria. The Cox proportional hazards model was used to estimate the hazard ratios (HR) and related 95% confidence intervals (95% CI) for the association between HBV infection and MS over a 20-year follow-up period.
resultsOf 976 subjects recruited, 480 had latent HBV infection (exposed subjects). After adjusting for age, the crude HR was 2.46 (95% CI: 1.77, 3.41). After adjusting for potential risk factors of MS (age, gender, smoking, passive smoking, alcohol consumption, physical activity, and diet), the HR was 2.27 (95% CI: 1.52, 3.38).
conclusionsThis 20-year follow-up retrospective cohort study in Shanghai showed a positive association between HBV infection and MS.
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