ArticleInternational journal of radiation biology2014
Total-body irradiation produces late degenerative joint damage in rats.
Article in International journal of radiation biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- MakoJournal of orthopaedics · 2023Article
- Induction of Accelerated Aging in a Mouse Model.Cells · 2022Review
- Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents.Scientific reports · 2021Article
- Evaluation of acute esophageal radiation-induced damage using magnetic resonance imaging: a feasibility study in mice.Radiation oncology (London, England) · 2019Article
- Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading.Radiation research · 2019Article
- The effects of low-dose radiation on articular cartilage: a review.Journal of biological engineering · 2019Review
- Dosimetry in Micro-computed Tomography: a Review of the Measurement Methods, Impacts, and Characterization of the Quantum GX Imaging System.Molecular imaging and biology · 2017Review
- A reproducible radiation delivery method for unanesthetized rodents during periods of hind limb unloading.Life sciences in space research · 2015Article
- Non-Invasive Quantification of Cartilage Using a Novel In Vivo Bioluminescent Reporter Mouse.PloS one · 2015Article
- Introduction to Michael E. Robbins memorial issue.International journal of radiation biology · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposePremature musculoskeletal joint failure is a major source of morbidity among childhood cancer survivors. Radiation effects on synovial joint tissues of the skeleton are poorly understood. Our goal was to assess long-term changes in the knee joint from skeletally mature rats that received total-body irradiation while skeletal growth was ongoing. MATERIALS AND
methods14 week-old rats were irradiated with 1, 3 or 7 Gy total-body doses of 18 MV X-rays. At 53 weeks of age, structural and compositional changes in knee joint tissues (articular cartilage, subchondral bone, and trabecular bone) were characterized using 7T MRI, nanocomputed tomography (nanoCT), microcomputed tomography (microCT), and histology.
resultsT2 relaxation times of the articular cartilage were lower after exposure to all doses. Likewise, calcifications were observed in the articular cartilage. Trabecular bone microarchitecture was compromised in the tibial metaphysis at 7 Gy. Mild to moderate cartilage erosion was scored in the 3 and 7 Gy rats.
conclusionsLate degenerative changes in articular cartilage and bone were observed after total-body irradiation in adult rats exposed prior to skeletal maturity. 7T MRI, microCT, nanoCT, and histology identified potential prognostic indicators of late radiation-induced joint damage.
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