Evidence map›Paper›PMID 24885631›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2014

25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype.

K S Jones, S Assar, D Harnpanich, R Bouillon, D Lambrechts, A Prentice, I Schoenmakers

Open access · hybridAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 6 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 6 syntheses or guidelines pooled it, 279 citations in OpenAlex.

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  12. Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
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  15. Longevity of daily oral vitamin D3 supplementation: differences in 25OHD and 24,25(OH)2D observed 2 years after cessation of a 1-year randomised controlled trial (VICtORy RECALL).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

K S JonesMedical Research Council Human Nutrition Research (K.S.J., S.A., D.H., A.P., I.S.), Cambridge CB1 9NL, United Kingdom; Medical Research Council Keneba (K.S.J., A.P.), The Gambia; Clinic and Laboratory of Experimental Medicine and Endocrinology (R.B.) and Laboratory for Translational Genetics (D.L.), Katholieke Universiteit, B-3000 Leuven, Belgium; and Vesalius Research Center (D.L.), VIB, Katholieke Universiteit, B-3000, Leuven, Belgium.
S Assar
D Harnpanich
R Bouillon
D Lambrechts
A Prentice
I Schoenmakers
Medical Research Council · GBKU Leuven · BEMRC Human Nutrition Research · GBMRC Unit the Gambia · GM

Funding

Medical Research Council MC_U105960371Medical Research Council MC_U123292701Medical Research Council U105960371Medical Research Council U123261351
6 · The paper itself

Abstract

contextThere is uncertainty over the equivalence of vitamins D2 and D3 to maintain plasma 25-hydroxyvitamin D (25(OH)D).

objectiveThe objective of the study was to compare the plasma half-lives of 25(OH)D2 and 25(OH)D3 in two distinct populations with different dietary calcium intake and 25(OH)D status.

participantsHealthy men (aged 24 and 39 y), resident in The Gambia (n = 18) or the United Kingdom (n = 18) participated in the study.

interventionsThe intervention included an oral tracer dose of deuterated-25(OH)D2 and deuterated-25(OH)D3 (both 40 nmol). Blood samples were collected over 33 days.

main outcome measures25(OH)D2 and 25(OH)D3 plasma half-lives, concentrations of 25(OH)D, and vitamin D binding protein (DBP) and DBP genotypes were measured.

results25(OH)D2 half-life [mean (SD)] [13.9 (2.6) d] was shorter than 25(OH)D3 half-life [15.1 (3.1) d; P = .001] for countries combined, and in Gambians [12.8 (2.3) d vs 14.7 (3.5) d; P < .001], but not in the United Kingdom [15.1 (2.4) d vs 15.6 (2.5) d; P = .3]. 25(OH)D concentration was 69 (13) and 29 (11) nmol/L (P < .0001), and the DBP concentration was 259 (33) and 269 (23) mg/L (P = .4) in The Gambia and United Kingdom, respectively. Half-lives were positively associated with plasma DBP concentration for countries combined [25(OH)D2 half-life: regression coefficient (SE) 0.03 (0.01) d per 1 mg/L DBP, P = .03; 25(OH)D3 half-life: 0.04 (0.02) d, P = .02] and in Gambians [25(OH)D2 half-life: 0.04 (0.01) d; P = .02; 25(OH)D3 half-life: 0.06 (0.02) d, P = .01] but not in UK participants. The DBP concentration × country interactions were not significant. DBP Gc1f/1f homozygotes had shorter 25(OH)D2 half-lives compared with other combined genotypes (P = .007) after correction for country.

conclusions25(OH)D2 half-life was shorter than 25(OH)D3 half-life, and half-lives were affected by DBP concentration and genotype. The stable isotope 25(OH)D half-life measurements provide a novel tool to investigate vitamin D metabolism and vitamin D expenditure and aid in the assessment of vitamin D requirements.

Indexed as

24,25-Dihydroxyvitamin D 325-Hydroxyvitamin D 2AdultCalcifediolCalcium, DietaryCytochrome P-450 Enzyme SystemCytochrome P450 Family 27DeuteriumGambiaGenotypeHumansLinear ModelsMaleModels, BiologicalParathyroid HormoneUnited Kingdom24,25-Dihydroxyvitamin D 325-Hydroxyvitamin D 2CalcifediolCalcium, DietaryCYP24A1 protein, humanCYP27C1 protein, humanCytochrome P-450 Enzyme SystemCytochrome P450 Family 27DeuteriumParathyroid HormoneVitamin D3 24-HydroxylaseVitamin D-Binding ProteinVitamins

Identifiers

PMID24885631
PMCPMC4207933
OpenAlexW2032874870

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.