ArticleNeural development2014
Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice.
Article in Neural development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Quantifying functional vision in a mouse model of oculocutaneous albinism type 1.Scientific reports · 2026Article
- Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine.Purinergic signalling · 2025Article
- Advancing Insights into Pediatric Macular Diseases: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Altered Functional Responses of the Retina in B6 Albino Tyrc/c Mice.Investigative ophthalmology & visual science · 2024Article
- Development of the Binocular Circuit.Annual review of neuroscience · 2024Review
- Visual Field Deficits in Albinism in Comparison to Idiopathic Infantile Nystagmus.Investigative ophthalmology & visual science · 2024Article
- Impaired Direction Selectivity in the Nucleus of the Optic Tract of Albino Mice.Investigative ophthalmology & visual science · 2023Article
- Pten inhibition dedifferentiates long-distance axon-regenerating intrinsically photosensitive retinal ganglion cells and upregulates mitochondria-associated Dynlt1a and Lars2.Development (Cambridge, England) · 2023Article
- CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism.Neuron · 2023Article
- TheGenes · 2022Article
- Abnormal Retinal Vessel Architecture in Albinism and Idiopathic Infantile Nystagmus.Investigative ophthalmology & visual science · 2022Article
- Analysis of mitochondrial dynamics and function in the retinal pigment epithelium by high-speed high-resolution live imaging.Frontiers in cell and developmental biology · 2022Article
- Serotonin transporter-mediated molecular axis regulates regional retinal ganglion cell vulnerability and axon regeneration after nerve injury.PLoS genetics · 2021Article
- Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?International journal of molecular sciences · 2021Review
- Atoh7-independent specification of retinal ganglion cell identity.Science advances · 2021Article
- Making sense of neural development by comparing wiring strategies for seeing and hearing.Science (New York, N.Y.) · 2021Review
- Article
- Neurogenesis and Specification of Retinal Ganglion Cells.International journal of molecular sciences · 2020Review
- How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits.eLife · 2019Article
- Wiring the Binocular Visual Pathways.International journal of molecular sciences · 2019Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundProper binocular vision depends on the routing at the optic chiasm of the correct proportion of retinal ganglion cell (RGC) axons that project to the same (ipsilateral) and opposite (contralateral) side of the brain. The ipsilateral RGC projection is reduced in mammals with albinism, a congenital disorder characterized by deficient pigmentation in the skin, hair, and eyes. Compared to the pigmented embryonic mouse retina, the albino embryonic mouse retina has fewer RGCs that express the zinc-finger transcription factor, Zic2, which is transiently expressed by RGCs fated to project ipsilaterally. Here, using Zic2 as a marker of ipsilateral RGCs, Islet2 as a marker of contralateral RGCs, and birthdating, we investigate spatiotemporal dynamics of RGC production as they relate to the phenotype of diminished ipsilateral RGC number in the albino retina.
resultsAt embryonic day (E)15.5, fewer Zic2-positive (Zic2+) RGCs are found in the albino ventrotemporal (VT) retina compared with the pigmented VT retina, as we previously reported. However, the reduction in Zic2+ RGCs in the albino is not accompanied by a compensatory increase in Zic2-negative (Zic2-) RGCs, resulting in fewer RGCs in the VT retina at this time point. At E17.5, however, the number of RGCs in the VT region is similar in pigmented and albino retinae, implicating a shift in the timing of RGC production in the albino. Short-term birthdating assays reveal a delay in RGC production in the albino VT retina between E13 and E15. Specifically, fewer Zic2+ RGCs are born at E13 and more Zic2- RGCs are born at E15. Consistent with an increase in the production of Zic2- RGCs born at later ages, more RGCs at E17.5 express the contralateral marker, Islet2, in the albino VT retina compared with the pigmented retina.
conclusionsA delay in neurogenesis in the albino retina is linked to the alteration of RGC subtype specification and consequently leads to the reduced ipsilateral projection that characterizes albinism.
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