Trial reportBMC psychiatry2014
Study protocol: The Whitehall II imaging sub-study.
Trial report in BMC psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03335696 (Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy), which is not on this map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy
Who cites it
57 citing papers in PubMed.
- Bupropion Administration Increases Resting-State Functional Connectivity in Dorso-Medial Prefrontal Cortex.The international journal of neuropsychopharmacology · 2017Trial
- The Relationship Between Hippocampal Cerebrovascular Reactivity and Brain Structure in Older Age.Human brain mapping · 2026Article
- High-sensitivity cardiac troponin I and risk of dementia: the 25-year longitudinal Whitehall II study.European heart journal · 2026Article
- Associations of aortic and carotid artery health with cerebrovascular markers and cognition in older adults from the Whitehall II imaging study.BMC medicine · 2025Article
- No significant association between self-reported physical activity and brain volumes in women and men from five European cohorts.Scientific reports · 2025Article
- Association of Diet and Waist-to-Hip Ratio With Brain Connectivity and Memory in Aging.JAMA network open · 2025Article
- Automated quality control of T1-weighted brain MRI scans for clinical research datasets: methods comparison and design of a quality prediction classifier.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Distinct patterns of connectivity with the motor cortex reflect different components of sensorimotor learning.PLoS biology · 2024Article
- Influence of intergenerational social mobility on brain structure and global cognition: findings from the Whitehall II study across 20 years.Age and ageing · 2024Article
- The Advanced BRain Imaging on ageing and Memory (ABRIM) data collection: Study design, data processing, and rationale.PloS one · 2024Article
- Do Left-Handed Older Adults Have Superior Visual Memories?Perceptual and motor skills · 2023Article
- Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Multiscale functional connectivity patterns of the aging brain learned from harmonized rsfMRI data of the multi-cohort iSTAGING study.NeuroImage · 2023Article
- Inter- and intra-individual variation in brain structural-cognition relationships in aging.NeuroImage · 2022Article
- Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Education and Income Show Heterogeneous Relationships to Lifespan Brain and Cognitive Differences Across European and US Cohorts.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
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- Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging.Human brain mapping · 2021Article
- Subjective Cognitive Complaints Given in Questionnaire: Relationship With Brain Structure, Cognitive Performance and Self-Reported Depressive Symptoms in a 25-Year Retrospective Cohort Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors.
Funding
Abstract
backgroundThe Whitehall II (WHII) study of British civil servants provides a unique source of longitudinal data to investigate key factors hypothesized to affect brain health and cognitive ageing. This paper introduces the multi-modal magnetic resonance imaging (MRI) protocol and cognitive assessment designed to investigate brain health in a random sample of 800 members of the WHII study. METHODS/
designA total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and will be completed by 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. Here, we describe the pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study. DISCUSSION: The integration of cutting-edge MRI techniques, clinical and cognitive tests in combination with retrospective data on social, behavioural and biological variables during the preceding 25 years from a well-established longitudinal epidemiological study (WHII cohort) will provide a unique opportunity to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.
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