ArticleBMC microbiology2014
RpoS integrates CRP, Fis, and PhoP signaling pathways to control Salmonella Typhi hlyE expression.
Article in BMC microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
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- Cytolysin A is an intracellularly induced and secreted cytotoxin of typhoidal Salmonella.Nature communications · 2024Article
- Review
- The rpoS gene confers resistance to low osmolarity conditions in Salmonella enterica serovar Typhi.PloS one · 2022Article
- Augmented Enterocyte Damage DuringFrontiers in cellular and infection microbiology · 2022Article
- CdsH Contributes to the Replication ofMicroorganisms · 2020Article
- Review
- Identification of Genes Involved in Biogenesis of Outer Membrane Vesicles (OMVs) inFrontiers in microbiology · 2019Article
- Regulation of Three Virulence Strategies of Mycobacterium tuberculosis: A Success Story.International journal of molecular sciences · 2018Review
- Systematic identification of novel regulatory interactions controlling biofilm formation in the bacterium Escherichia coli.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSPI-18 is a pathogenicity island found in some Salmonella enterica serovars, including S. Typhi. SPI-18 harbors two ORFs organized into an operon, hlyE and taiA genes, both implicated in virulence. Regarding the hlyE regulation in S. Typhi, it has been reported that RpoS participates as transcriptional up-regulator under low pH and high osmolarity. In addition, CRP down-regulates hlyE expression during exponential growth. Previously, it has been suggested that there is another factor related to catabolite repression, different from CRP, involved in the down-regulation of hlyE. Moreover, PhoP-dependent hlyE up-regulation has been reported in bacteria cultured simultaneously under low pH and low concentration of Mg2+. Nevertheless, the relative contribution of each environmental signal is not completely clear. In this work we aimed to better understand the regulation of hlyE in S. Typhi and the integration of different environmental signals through global regulators.
resultsWe found that Fis participates as a CRP-independent glucose-dependent down-regulator of hlyE. Also, Fis and CRP seem to exert the repression over hlyE through down-regulating rpoS. Moreover, PhoP up-regulates hlyE expression via rpoS under low pH and low Mg2+ conditions.
conclusionsAll these results together show that, at least under the tested conditions, RpoS is the central regulator in the hlyE regulatory network, integrating multiple environmental signals and global regulators.
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