ArticleJournal of translational medicine2014
Overexpression of IL-17RC associated with ocular sarcoidosis.
Article in Journal of translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Emerging Molecular Targets for the Treatment of Refractory Sarcoidosis.Frontiers in medicine · 2020Review
- Identifying Novel Biomarkers in Sarcoidosis Using Genome-Based Approaches.Clinics in chest medicine · 2015Review
- The role of sex in uveitis and ocular inflammation.International ophthalmology clinics · 2015Review
- Low dose corticosteroid in association with methotrexate for therapy of ocular sarcoidosis: report of a case.International journal of retina and vitreous · 2015Article
- Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity.SpringerPlus · 2014Article
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Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSarcoidosis is a chronic inflammatory disease with a systemic granulomatous disorder affecting multiple organs including the eye. Both CD4+ T cell and macrophage have been linked to the pathogenesis of the disease.
methodsThe expression of IL-17RC was measured using FACS,immunohistochemistry and real-time PCR. Serum level of IL-17 was detected using ELISA.
resultsAn elevated expression of IL-17RC on CD8+ T cells in peripheral blood was found in patients with ocular sarcoidosis as compared to healthy controls. Interestingly, we found a significant increase in the serum level of IL-17 in patients with ocular sarcoidosis as compared to healthy controls, which may be responsible for the induction of IL-17RC on CD8+ cells. In addition, IL-17RC appeared only in the retinal tissue of the patient with clinically active sarcoidosis.
conclusionsOur results suggested a potential involvement of IL-17RC+CD8+ T cells in pathogenesis of ocular sarcoidosis.
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Registered trials
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