ArticleBMC pulmonary medicine2014
Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts.
Article in BMC pulmonary medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02975258 (Adiposity and Airway Inflammation in HIV-Associated Airway Disease), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adiposity and Airway Inflammation in HIV-Associated Airway Disease
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Effect of HIV on respiratory symptoms, health status, and exertional capacity.AIDS (London, England) · 2025Pooled it
- Effect of Human Immunodeficiency Virus on Lung Function and Structure: A Systematic Review and Meta-Analysis.Annals of the American Thoracic Society · 2025Pooled it
- Pooled it
- Echocardiography in HIV Disease.Current cardiology reports · 2026Review
- Unraveling the impact of indoor air pollution on respiratory health in people living with HIV within a high-prevalence HIV cohort.BMC pulmonary medicine · 2025Article
- Sequelae of Immunocompromised Host Pneumonia.Clinics in chest medicine · 2025Review
- Variations in the sleep-related breathing disorder index on polysomnography between men with HIV and controls: a matched case-control study.BMC infectious diseases · 2024Article
- The relationship between autophagy and respiratory viruses.Archives of microbiology · 2024Review
- Pulmonary Function and Quality of Life in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study.AIDS research and human retroviruses · 2023Article
- Two pandemics intertwined around one patient: Interstitial pneumonia as the first presentation of HIV/AIDS, be itHeliyon · 2023Article
- HIV-associated lung disease.Nature reviews. Disease primers · 2023Review
- COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.International journal of chronic obstructive pulmonary disease · 2023Review
- Pulmonary and physical function limitations in aging men with and without HIV from the Multicenter AIDS Cohort Study (MACS).Annals of epidemiology · 2022Article
- Pulmonary Function Trajectories in People with HIV: Analysis of the Pittsburgh HIV Lung Cohort.Annals of the American Thoracic Society · 2022Article
- Dyspnea and Pulmonary Function Among Participants in the Multicenter AIDS Cohort Study Using Protease Inhibitors: A Cross-Sectional Study.AIDS research and human retroviruses · 2022Article
- Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis.The Journal of clinical investigation · 2021Article
- Differences in Sleep Disorders between HIV-Infected Persons and Matched Controls with Sleep Problems: A Matched-Cohort Study Based on Laboratory and Survey Data.Journal of clinical medicine · 2021Article
- Article
- Diagnosis and Management of HIV-Associated Pulmonary Diseases in a Ryan White-Funded Primary Care Setting.AIDS patient care and STDs · 2021Article
- Predictors of impaired pulmonary function in people living with HIV in an urban African setting.Southern African journal of HIV medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundSeveral lung diseases are increasingly recognized as comorbidities with HIV; however, few data exist related to the spectrum of respiratory symptoms, diagnostic testing, and diagnoses in the current HIV era. The objective of the study is to determine the impact of HIV on prevalence and incidence of respiratory disease in the current era of effective antiretroviral treatment.
methodsA pulmonary-specific questionnaire was administered yearly for three years to participants in the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS). Adjusted prevalence ratios for respiratory symptoms, testing, or diagnoses and adjusted incidence rate ratios for diagnoses in HIV-infected compared to HIV-uninfected participants were determined. Risk factors for outcomes in HIV-infected individuals were modeled.
resultsBaseline pulmonary questionnaires were completed by 907 HIV-infected and 989 HIV-uninfected participants in the MACS cohort and by 1405 HIV-infected and 571 HIV-uninfected participants in the WIHS cohort. In MACS, dyspnea, cough, wheezing, sleep apnea, and incident chronic obstructive pulmonary disease (COPD) were more common in HIV-infected participants. In WIHS, wheezing and sleep apnea were more common in HIV-infected participants. Smoking (MACS and WIHS) and greater body mass index (WIHS) were associated with more respiratory symptoms and diagnoses. While sputum studies, bronchoscopies, and chest computed tomography scans were more likely to be performed in HIV-infected participants, pulmonary function tests were no more common in HIV-infected individuals. Respiratory symptoms in HIV-infected individuals were associated with history of pneumonia, cardiovascular disease, or use of HAART. A diagnosis of asthma or COPD was associated with previous pneumonia.
conclusionsIn these two cohorts, HIV is an independent risk factor for several respiratory symptoms and pulmonary diseases including COPD and sleep apnea. Despite a higher prevalence of chronic respiratory symptoms, testing for non-infectious respiratory diseases may be underutilized in the HIV-infected population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.