ArticleBMC neuroscience2014
Common genetic variation of the APOE gene and personality.
Article in BMC neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial.BMC geriatrics · 2017Trial
- Association between Apolipoprotein E gene polymorphism and the tortuosity of extracranial carotid artery.Frontiers in neurology · 2025Article
- Personality and Incident Alzheimer's Disease: Theory, Evidence, and Future Directions.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020Review
- Associations of APOE ε4 With Health and Financial Literacy Among Community-Based Older Adults Without Dementia.The journals of gerontology. Series B, Psychological sciences and social sciences · 2018Article
- The synergistic risk effect of apolipoprotein ε4 and DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B) haplotype for Alzheimer's disease.Molecular biology reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA recent study yielded first evidence that personality plays an important role in explaining the influence of a prominent APOE polymorphism on cognitive decline and Alzheimer's disease (AD) in elderly humans. Adding to this, two earlier studies examined this polymorphism in the context of individual differences in temperament traits in young humans with mixed results. In general, research linking the prominent APOE ϵ2, ϵ3 and ϵ4 variants and human personality is of special interest, because an influence of this gene and its prominent polymorphism on personality in young adulthood could be of diagnostic value to predict AD and its development in later years.
resultsIn the present study N = 531 participants provided buccal swabs and filled in a self-report inventory measuring the Five Factor Model of Personality. No association between common genetic variations of the APOE gene (in detail the genotypes ϵ3/ϵ3, ϵ2/ϵ3 and ϵ3/ϵ4) and personality could be observed. The remaining genotypes, including the high risk constellation ϵ4/ϵ4 for AD, were too seldom to be tested.
conclusionsIn sum, the present study yielded no evidence for a direct link between common genetic variants of the APOE gene and personality in young adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.