Observational studyBMC ophthalmology2014
An easy method to differentiate retinal arteries from veins by spectral domain optical coherence tomography: retrospective, observational case series.
Observational study in BMC ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Retinal Vessel Caliber Measurement Bias in Fundus Images in the Presence of the Central Light Reflex.Translational vision science & technology · 2023Article
- Polarization properties of retinal blood vessel walls measured with polarization sensitive optical coherence tomography.Biomedical optics express · 2021Article
- Differential artery-vein analysis in quantitative retinal imaging: a review.Quantitative imaging in medicine and surgery · 2021Review
- Vascular morphology and blood flow signatures for differential artery-vein analysis in optical coherence tomography of the retina.Biomedical optics express · 2021Article
- Seeking clarity on retinal findings in patients with COVID-19.Lancet (London, England) · 2020Article
- Quantitative optical coherence tomography angiography: A review.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- An Unusual Retinal Vessel Modification in Patients Affected by JIA-Uveitis with a Follow-Up Longer Than 16 Years.Case reports in ophthalmological medicine · 2020Article
- In vivo identification of arteries and veins using two-photon excitation elastin autofluorescence.Journal of anatomy · 2020Article
- Near infrared oximetry-guided artery-vein classification in optical coherence tomography angiography.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- The use of transdermal optical coherence tomography to image the superficial temporal arteries.Eye (London, England) · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently it was shown that retinal vessel diameters could be measured using spectral domain optical coherence tomography (OCT). It has also been suggested that retinal vessels manifest different features on spectral domain OCT (SD-OCT) depending on whether they are arteries or veins. Our study was aimed to present a reliable SD-OCT assisted method of differentiating retinal arteries from veins.
methodsPatients who underwent circular OCT scans centred at the optic disc using a Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) were retrospectively reviewed. Individual retinal vessels were identified on infrared reflectance (IR) images and given unique labels for subsequent grading. Vessel types (artery, vein or uncertain) assessed by IR and/or fluorescein angiography (FA) were referenced as ground truth. From OCT, presence/absence of the hyperreflective lower border reflectivity feature was assessed. Presence of this feature was considered indicative for retinal arteries and compared with the ground truth.
resultsA total of 452 vessels from 26 eyes of 18 patients were labelled and 398 with documented vessel type (302 by IR and 96 by FA only) were included in the study. Using SD-OCT, 338 vessels were assigned a final grade, of which, 86.4% (292 vessels) were classified correctly. Forty three vessels (15 arteries and 28 veins) that IR failed to differentiate were correctly classified by SD-OCT. When using only IR based ground truth for vessel type the SD-OCT based classification approach reached a sensitivity of 0.8758/0.9297, and a specificity of 0.9297/0.8758 for arteries/veins, respectively.
conclusionOur method was able to classify retinal arteries and veins with a commercially available SD-OCT alone, and achieved high classification performance. Paired with OCT based vessel measurements, our study has expanded the potential clinical implication of SD-OCT in evaluation of a variety of retinal and systemic vascular diseases.
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