ArticleBMC pulmonary medicine2014
Altered mucosal immune response after acute lung injury in a murine model of Ataxia Telangiectasia.
Article in BMC pulmonary medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Immune profiling and functional analysis of NK and T cells in ataxia telangiectasia.Frontiers in immunology · 2024Article
- Ataxia telangiectasia mutated is required for efficient proximal airway epithelial cell regeneration following influenza A virus infection.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease.Scientific reports · 2021Article
- Article
- Review
- Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis.Mucosal immunology · 2018Article
- Oxidative stress-driven pulmonary inflammation and fibrosis in a mouse model of human ataxia-telangiectasia.Redox biology · 2018Article
- The Basic Science and Molecular Mechanisms of Lung Injury and Acute Respiratory Distress Syndrome.International anesthesiology clinics · 2018Review
- Ataxia telangiectasia: a review.Orphanet journal of rare diseases · 2016Review
- Low-dose irradiation prior to bone marrow transplantation results in ATM activation and increased lethality in Atm-deficient mice.Bone marrow transplantation · 2016Article
- DNA Damage: From Chronic Inflammation to Age-Related Deterioration.Frontiers in genetics · 2016Review
- Article
- A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease.Human molecular genetics · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtaxia telangiectasia (A-T) is a rare but devastating and progressive disorder characterized by cerebellar dysfunction, lymphoreticular malignancies and recurrent sinopulmonary infections. In A-T, disease of the respiratory system causes significant morbidity and is a frequent cause of death.
methodsWe used a self-limited murine model of hydrochloric acid-induced acute lung injury (ALI) to determine the inflammatory answer due to mucosal injury in Atm (A-T mutated)- deficient mice (Atm(-/-)).
resultsATM deficiency increased peak lung inflammation as demonstrated by bronchoalveolar lavage fluid (BALF) neutrophils and lymphocytes and increased levels of BALF pro-inflammatory cytokines (e.g. IL-6, TNF). Furthermore, bronchial epithelial damage after ALI was increased in Atm(-/-) mice. ATM deficiency increased airway resistance and tissue compliance before ALI was performed.
conclusionsTogether, these findings indicate that ATM plays a key role in inflammatory response after airway mucosal injury.
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