ArticleEnvironmental health : a global access science source2014
Mitochondrial haplogroups modify the effect of black carbon on age-related cognitive impairment.
Article in Environmental health : a global access science source, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature.Environmental health perspectives · 2021Pooled it
- A critical review of potential modifiers of air pollutant associations with dementia and related outcomes.Neurotoxicology · 2026Review
- Article
- Maternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods.Environment international · 2022Article
- The pathogenic effects of particulate matter on neurodegeneration: a review.Journal of biomedical science · 2022Review
- Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study.PLoS medicine · 2022Article
- Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry.Mitochondrion · 2022Article
- Associations Between Maternal Lifetime Stress and Placental Mitochondrial DNA Mutations in an Urban Multiethnic Cohort.Biological psychiatry · 2021Article
- Neurodegenerative hospital admissions and long-term exposure to ambient fine particle air pollution.Annals of epidemiology · 2021Article
- Association of Long-term Ambient Black Carbon Exposure and Oxidative Stress Allelic Variants With Intraocular Pressure in Older Men.JAMA ophthalmology · 2019Article
- Effect of untreated pharmaceutical plant effluent on cardiac NaToxicology reports · 2019Article
- Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age.Environmental science & technology · 2017Article
- Associations between long-term exposure to PMEnvironment international · 2017Article
- Integrating mitochondriomics in children's environmental health.Journal of applied toxicology : JAT · 2015Review
- Mitochondrial functional impairment in response to environmental toxins in the cardiorenal metabolic syndrome.Archives of toxicology · 2015Review
- Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study.BMC psychiatry · 2014Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundTraffic-related air pollution has been linked with impaired cognition in older adults, possibly due to effects of oxidative stress on the brain. Mitochondria are the main source of cellular oxidation. Haplogroups in mitochondrial DNA (mtDNA) mark individual differences in oxidative potential and are possible determinants of neurodegeneration. The aim of this study was to investigate whether mtDNA haplogroups determined differential susceptibility to cognitive effects of long-term exposure to black carbon (BC), a marker of traffic-related air pollution.
methodsWe investigated 582 older men (72 ± 7 years) in the VA Normative Aging Study cohort with ≤4 visits per participant (1.8 in average) between 1995-2007. Low (≤25) Mini Mental State Examination (MMSE) was used to assess impaired cognition in multiple domains. We fitted repeated-measure logistic regression using validated-LUR BC estimated in the year before their first visit at the participant's address.
resultsMitochondrial haplotyping identified nine haplogroups phylogenetically categorized in four clusters. BC showed larger effect on MMSE in Cluster 4 carriers, including I, W and X haplogroups, [OR = 2.7; 95% CI (1.3-5.6)], moderate effect in Cluster 1, including J and T haplogroups [OR = 1.6; 95% CI: (0.9-2.9)], and no effect in Cluster 2 (H and V haplogroups) [OR = 1.1; 95% CI: (0.8-1.5)] or Cluster 3 (K and U haplogroups) [OR = 1.0; 95% CI: (0.6-1.6)]. BC effect varied only moderately across the I, X, and W haplogroups or across the J and T haplogroups.
conclusionsThe association of BC with impaired cognition was worsened in carriers of phylogenetically-related mtDNA haplogroups in Cluster 4. No BC effects were detected in Cluster 2 and 3 carriers. MtDNA haplotypes may modify individual susceptibility to the particle cognitive effects.
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