ArticleBMC genomics2014
EPAS1 gene variants are associated with sprint/power athletic performance in two cohorts of European athletes.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The Genetic Profile of Combat Sport Athletes: A Systematic Review of Physiological, Psychological and Injury Risk Determinants.International journal of environmental research and public health · 2024Pooled it
- Weighted total genotype score associated with knee ligament injury incidence in adolescent female basketball athletes.BMC sports science, medicine & rehabilitation · 2026Article
- EPAS1 is associated with human muscle fiber composition and endurance phenotypes.Physiological reports · 2026Article
- A novel combination of genomic loci inBiology of sport · 2026Article
- Intelligent monitoring and individualized strategies for preventing altitude sickness during altitude training.Frontiers in physiology · 2025Review
- Influence of genetic polymorphism on sports talent performance versus non-athletes: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2024Article
- Brain gene expression reveals pathways underlying nocturnal migratory restlessness.Scientific reports · 2024Article
- A critical examination of sport discipline typology: identifying inherent limitations and deficiencies in contemporary classification systems.Frontiers in physiology · 2024Article
- Adaptive Regulation of Stopover Refueling during Bird Migration: Insights from Whole Blood Transcriptomics.Genome biology and evolution · 2023Article
- Uncovering the Bone-Muscle Interaction and Its Implications for the Health and Function of Older Adults (the Wellderly Project): Protocol for a Randomized Controlled Crossover Trial.JMIR research protocols · 2021Article
- Genetic Markers Associated with Power Athlete Status.Journal of human kinetics · 2019Article
- The Potential Role of Genetic Markers in Talent Identification and Athlete Assessment in Elite Sport.Sports (Basel, Switzerland) · 2018Review
- EndothelialJournal of the American Society of Nephrology : JASN · 2017Article
- The gene SMART study: method, study design, and preliminary findings.BMC genomics · 2017Review
- Article
- ACVR1B rs2854464 Is Associated with Sprint/Power Athletic Status in a Large Cohort of Europeans but Not Brazilians.PloS one · 2016Article
- Elite athletes' genetic predisposition for altered risk of complex metabolic traits.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe endothelial PAS domain protein 1 (EPAS1) activates genes that are involved in erythropoiesis and angiogenesis, thus favoring a better delivery of oxygen to the tissues and is a plausible candidate to influence athletic performance. Using innovative statistical methods we compared genotype distributions and interactions of EPAS1 SNPs rs1867785, rs11689011, rs895436, rs4035887 and rs1867782 between sprint/power athletes (n=338), endurance athletes (n=254), and controls (603) in Polish and Russian samples. We also examined the association between these SNPs and the athletes' competition level ('elite' and 'sub-elite' level). Genotyping was performed by either Real-Time PCR or by Single-Base Extension (SBE) method.
resultsIn the pooled cohort of Polish and Russian athletes, 1) rs1867785 was associated with sprint/power athletic status; the AA genotype in rs1867785 was underrepresented in the sprint/power athletes, 2) rs11689011 was also associated with sprint/power athletic status; the TT genotype in rs11689011 was underrepresented sprint/power athletes, and 3) the interaction between rs1867785, rs11689011, and rs4035887 was associated with sprint/power athletic performance; the combinations of the AA genotype in rs4035887 with either the AG or GG genotypes in rs1867785, or with the CT or CC genotypes in rs11689011, were underrepresented in two cohorts of sprint/power athletes.
conclusionsBased on the unique statistical model rs1867785/rs11689011 are strong predictors of sprint/power athletic status, and the interaction between rs1867785, rs11689011, and rs4035887 might contribute to success in sprint/power athletic performance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.