ArticleIndoor air2014
Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development.
Article in Indoor air, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.
- Childhood asthma and mould in homes-A meta-analysis.Wiener klinische Wochenschrift · 2025Pooled it
- Characterization of Airborne Fungal Diversity in Nunavik Housing Using Activated Air Sampling.ACS ES&T air · 2026Article
- Domestic fungal exposure and asthma morbidity in New York City children following Superstorm Sandy.Journal of exposure science & environmental epidemiology · 2026Article
- Early Environments, Lasting Effects: Air Pollution, Microbes, and Respiratory Infection Risk in Children.Pediatric pulmonology · 2026Review
- Characterization of the bacterial and fungal diversity in habitats of Corsica Island.Applied and environmental microbiology · 2025Article
- The association between preschoolers' retinal microcirculation and the indoor microbial environment: results of the ENVIRONAGE birth cohort.Scientific reports · 2025Article
- Exposure to elevated relative humidity in laboratory chambers alters fungal gene expression in dust from the International Space Station (ISS).Scientific reports · 2025Article
- Fungal Microbiome Diversity in Urban Forest Decreases Asthma and Allergic Inflammation.Allergy, asthma & immunology research · 2025Article
- More diverse school microbiota may provide better protection against respiratory infections for school staff.Building and environment · 2025Article
- Indoor bioaerosols and asthma: Overview, implications, and mitigation strategies.The Journal of allergy and clinical immunology · 2025Review
- Inspection confirmed mold damage in schools and new use of drugs for airway obstruction: A cohort study.PloS one · 2025Article
- Moving beyond species: fungal function in house dust provides novel targets for potential indicators of mold growth in homes.Microbiome · 2024Article
- Fungal diversity differences in the indoor dust microbiome from built environments on earth and in space.Scientific reports · 2024Article
- Fungal Spore Richness and Abundance of Allergenic Taxa: Comparing a Portable Impactor and Passive Trap Indoors and Outdoors in an Urban Setting.Microbial ecology · 2024Article
- ITS and 16S rRNA Gene Revealed Multitudinous Microbial Contaminations of Residential Air Conditioning Filters in Megacity Shanghai, China.Environment & health (Washington, D.C.) · 2024Article
- Fungal diversity in homes and asthma morbidity among school-age children in New York City.Environmental research · 2023Article
- Fungi in Early-Life House Dust Samples and the Development of Asthma: A Birth Cohort Study.Annals of the American Thoracic Society · 2023Article
- PersistingFrontiers in cellular and infection microbiology · 2023Article
- Indoor bacterial and fungal aerosols as predictors of lower respiratory tract infections among under-five children in Ibadan, Nigeria.BMC pulmonary medicine · 2022Article
- Spring is associated with increased total and allergenic fungal concentrations in house dust from a pediatric asthma cohort in New York City.Building and environment · 2022Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
unlabelledDampness and visible mold in homes are associated with asthma development, but causal mechanisms remain unclear. The goal of this research was to explore associations among measured dampness, fungal exposure, and childhood asthma development without the bias of culture-based microbial analysis. In the low-income, Latino CHAMACOS birth cohort, house dust was collected at age 12 months, and asthma status was determined at age 7 years.The current analysis included 13 asthma cases and 28 controls. Next-generation DNA sequencing methods quantified fungal taxa and diversity. Lower fungal diversity (number of fungal operational taxonomic units) was significantly associated with increased risk of asthma development: unadjusted odds ratio(OR) 4.80 (95% confidence interval (CI) 1.04–22.1). Control for potential confounders strengthened this relationship. Decreased diversity within the genus Cryptococcus was significantly associated with increased asthma risk (OR 21.0, 95% CI 2.16–204). No fungal taxon (species, genus, class) was significantly positively associated with asthma development, and one was significantly negatively associated. Elevated moisture was associated with increased fungal diversity, and moisture/mold indicators were associated with four fungal taxa. Next-generation DNA sequencing provided comprehensive estimates of fungal identity and diversity, demonstrating significant associations between low fungal diversity and childhood asthma development in this community. PRACTICAL IMPLICATIONS: Early life exposure to low fungal diversity in house dust was associated with increased risk for later asthma developmen tin this low-income, immigrant community. No individual fungal taxon (species, genus, or class) was associated with asthma development, although exposure to low diversity within the genus Cryptococcus was associated with asthma development. Future asthma development studies should incorporate fungal diversity measurements, in addition to measuring individual fungal taxa. These results represent a step toward identifying the aspect(s) of indoor microbial populations that are associated with asthma development and suggest that understanding the factors that control diversity in the indoor environment may lead to public health recommendations for asthma prevention in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.