Evidence map›Paper›PMID 24883337›Full record

ArticleAnnals of clinical and translational neurology2014

β1-adrenergic receptor activation enhances memory in Alzheimer's disease model.

Laurence Coutellier, Pooneh Memar Ardestani, Mehrdad Shamloo

Open access · goldAbstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

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  9. Medial septum: relevance for social memory.Frontiers in neural circuits · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Laurence CoutellierBehavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA, USA.
Pooneh Memar ArdestaniDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA ; Behavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA, USA.
Mehrdad ShamlooDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA ; Behavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA, USA.
Stanford University · US

Funding

VECTOR COREP30NS069375 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2011 to 2019
$6.3M
Role of beta adrenergic receptors in modulation of cognition, pathology and neuroinflammation in Alzheimer's DiseaseR21NS097945 · NINDS · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2016 to 2017
$443k
NINDS NIH HHS P30 NS069375NINDS NIH HHS R21 NS097945
6 · The paper itself

Abstract

objectiveDeficits in social recognition and learning of social cues are major symptoms of neurodegenerative disorders such as Alzheimer's disease (AD). Here we studied the role of β

methodsUsing pharmacological, biochemical and behavioral tools, we assessed social recognition and the β

resultsOur results demonstrated that APP mice display a significant social recognition deficit which is dependent on the β

interpretationOur data indicate that activation of β

Indexed as

Alzheimer’s diseasecognitive enhancersCREB phosphorylationmedial amygdalamemorysocial recognitionβ1-adrenergic receptor

Identifiers

PMID24883337
PMCPMC4036739
OpenAlexW1972091591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.