Evidence map›Paper›PMID 24883322›Full record

ArticleBioMed research international2014

The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation.

V Cervelli, S Garcovich, A Bielli, G Cervelli, B C Curcio, M G Scioli, A Orlandi, P Gentile

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 7 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 7 syntheses or guidelines pooled it, 256 citations in OpenAlex.

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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

V CervelliPlastic and Reconstructive Surgery Department, University of Rome Tor Vergata, Via Montpellier, No. 1, 00173 Rome, Italy.
S GarcovichInstitute of Dermatology, Catholic University of the Sacred Heart, Rome, Italy.
A BielliInstitute of Anatomic Pathology, University of Rome Tor Vergata, Via Montpellier, No. 1, 00173 Rome, Italy.
G CervelliScience Education Department, University of Rome Tor Vergata, Via Montpellier, No. 1, 00173 Rome, Italy.
B C CurcioPlastic and Reconstructive Surgery Department, University of Rome Tor Vergata, Via Montpellier, No. 1, 00173 Rome, Italy.
M G ScioliInstitute of Anatomic Pathology, University of Rome Tor Vergata, Via Montpellier, No. 1, 00173 Rome, Italy.
A OrlandiInstitute of Anatomic Pathology, University of Rome Tor Vergata, Via Montpellier, No. 1, 00173 Rome, Italy.
P GentilePlastic and Reconstructive Surgery Department, University of Rome Tor Vergata, Via Montpellier, No. 1, 00173 Rome, Italy ; San Salvatore in Lauro Place, No. 15, 00186 Rome, Italy.
University of Rome Tor Vergata · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the safety and clinical efficacy of AA-PRP injections for pattern hair loss. AA-PRP, prepared from a small volume of blood, was injected on half of the selected patients' scalps with pattern hair loss. The other half was treated with placebo. Three treatments were given for each patient, with intervals of 1 month. The endpoints were hair re-growth, hair dystrophy as measured by dermoscopy, burning or itching sensation, and cell proliferation as measured by Ki-67 evaluation. At the end of the 3 cycles of treatment, the patients presented clinical improvement in the mean number of hairs, with a mean increase of 18.0 hairs in the target area, and a mean increase in total hair density of 27.7 ( number of hairs/cm(2)) compared with baseline values. Microscopic evaluation showed the increase of epidermis thickness and of the number of hair follicles two weeks after the last AA-PRP treatment compared to baseline value (P < 0.05). We also observed an increase of Ki67(+) keratinocytes of epidermis and of hair follicular bulge cells and a slight increase of small blood vessels around hair follicles in the treated skin compared to baseline (P < 0.05).

Indexed as

AdultAlopeciaCell ProliferationEpidermisHair FollicleHumansInjectionsKeratinocytesMaleMiddle AgedPlatelet-Rich PlasmaScalp

Identifiers

PMID24883322
PMCPMC4032742
OpenAlexW2081311102

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.