ArticleBioMed research international2014
Cortisol is an associated-risk factor of brain dysfunction in patients with severe sepsis and septic shock.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Unveiling neurogenic biomarkers for the differentiation between sepsis patients with or without encephalopathy: an updated meta-analysis.Systematic reviews · 2025Pooled it
- Factors contributing to sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Diagnostic and prognostic value of serum S100B in sepsis-associated encephalopathy: A systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Blood-based biomarkers and delirium in critically ill adults in the ICU: a systematic review.Intensive care medicine experimental · 2026Review
- Cyclodextrin Inclusion Complexes with Hydrocortisone-Type Corticosteroids.Pharmaceutics · 2024Review
- Delirium in the ICU: how much do we know? A narrative review.Annals of medicine · 2024Review
- Article
- Meta-analysis of serological biomarkers at hospital admission for the likelihood of developing delirium during hospitalization.Frontiers in neurology · 2023Article
- FermentedInternational journal of molecular sciences · 2022Article
- Nanostructured Cyclodextrin-Mediated Surface for Capacitive Determination of Cortisol in Multiple Biofluids.ACS applied materials & interfaces · 2022Article
- Article
- Sleep and circadian rhythm disturbances in intensive care unit (ICU)-acquired delirium: a case-control study.The Journal of international medical research · 2021Article
- Glucocorticoids and the Brain after Critical Illness.Endocrinology · 2021Review
- Sickness Behavior Score Is Associated with Neuroinflammation and Late Behavioral Changes in Polymicrobial Sepsis Animal Model.Inflammation · 2020Article
- The dynamic change of serum S100B levels from day 1 to day 3 is more associated with sepsis-associated encephalopathy.Scientific reports · 2020Article
- Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3Mediators of inflammation · 2020Article
- Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?Frontiers in neurology · 2020Review
- Administration of Asian Herb Bennet (Nutrients · 2019Article
- Update of Sepsis in the Intensive Care Unit.Journal of innate immunity · 2017Review
- Influence of Ward Noise on Emotional State and Sleep Quality in Patients with Ventilator-induced Diaphragmatic Dysfunction.Noise & healthArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesTo investigate cortisol levels in brain dysfunction in patients with severe sepsis and septic shock.
methodsIn 128 septic and sedated patients, we studied brain dysfunction including delirium and coma by the evaluation of Richmond Agitation Sedation Scale (RASS), the Confusion Method Assessment in the ICU (CAM-ICU) after sedation withdrawal and the measurement of serum S100B biomarker of brain injury. Serum cortisol and S100B were measured within 12 hours after ICU admission and daily over the next four days.
resultsBrain dysfunction was observed in 50% (64/128) before but in 84% (107/128) of patients after sedation withdrawal, and was more common in the patients older than 57 years (P = 0.009). Both cortisol (P = 0.007) and S100B levels (P = 0.028) were higher in patients with than patients without brain dysfunction. Cortisol levels were associated with ICU mortality (hazard ratio = 1.17, P = 0.024). Multivariate logistic regression showed that cortisol (odds ratio (OR): 2.34, 95% CI (2.01, 3.22), P = 0.02) and the combination effect of cortisol with age (OR: 1.004, 95% CI (1.002, 1.93), P = 0.038) but not S100B were associated with brain dysfunction.
conclusionsCortisol was an associated-risk factor of brain dysfunction in patients with severe sepsis and septic shock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.