ArticleTheranostics2014
Simultaneous mapping of pan and sentinel lymph nodes for real-time image-guided surgery.
Article in Theranostics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Image-Guided Monitoring of Mitochondria and Blood-Brain Barrier Dysfunction in Amyotrophic Lateral Sclerosis Mice.Biomaterials research · 2025Article
- Indocyanine Blue (ICB) as a Functional Alternative to Indocyanine Green (ICG) for Enhanced 700 nm NIR Imaging.International journal of molecular sciences · 2024Article
- The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery.Journal of nanobiotechnology · 2022Review
- Methylene Blue and Proflavine as Intraarterial Marker for Functional Perforazome-Comparative Study.Journal of personalized medicine · 2021Article
- Small Molecules for Multi-Wavelength Near-Infrared Fluorescent Mapping of Regional and Sentinel Lymph Nodes in Colorectal Cancer Staging.Frontiers in oncology · 2020Article
- Near-Infrared Contrast Agents for Bone-Targeted Imaging.Tissue engineering and regenerative medicine · 2019Review
- Real-Time Fluorescence Imaging in Thoracic Surgery.The Korean journal of thoracic and cardiovascular surgery · 2019Article
- Intraoperative biophotonic imaging systems for image-guided interventions.Nanophotonics (Berlin, Germany) · 2019Article
- Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2018Article
- Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy.Theranostics · 2018Article
- Structure-Inherent Targeting of Near-Infrared Fluorophores for Image-Guided Surgery.Chonnam medical journal · 2017Review
- Sentinel Lymph Nodes Mapping in Cervical Cancer a Comprehensive Review.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2017Review
- Endocrine-specific NIR fluorophores for adrenal gland targeting.Chemical communications (Cambridge, England) · 2016Article
- Near-Infrared Illumination of Native Tissues for Image-Guided Surgery.Journal of medicinal chemistry · 2016Article
- Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer.BMC cancer · 2016Article
- Sentinel Lymph Node Mapping of Liver.Annals of surgical oncology · 2015Article
- Article
- Lymphatic imaging: focus on imaging probes.Theranostics · 2015Review
- Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery.Theranostics · 2015Article
- Phosphonated near-infrared fluorophores for biomedical imaging of bone.Angewandte Chemie (International ed. in English) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
The resection of regional lymph nodes in the basin of a primary tumor is of paramount importance in surgical oncology. Although sentinel lymph node mapping is now the standard of care in breast cancer and melanoma, over 20% of patients require a completion lymphadenectomy. Yet, there is currently no technology available that can image all lymph nodes in the body in real time, or assess both the sentinel node and all nodes simultaneously. In this study, we report an optical fluorescence technology that is capable of simultaneous mapping of pan lymph nodes (PLNs) and sentinel lymph nodes (SLNs) in the same subject. We developed near-infrared fluorophores, which have fluorescence emission maxima either at 700 nm or at 800 nm. One was injected intravenously for identification of all regional lymph nodes in a basin, and the other was injected locally for identification of the SLN. Using the dual-channel FLARE intraoperative imaging system, we could identify and resect all PLNs and SLNs simultaneously. The technology we describe enables simultaneous, real-time visualization of both PLNs and SLNs in the same subject.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.