ArticleEvidence-based complementary and alternative medicine : eCAM2014
Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model.
Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review.Frontiers in pharmacology · 2020Article
- Effect ofMedicina (Kaunas, Lithuania) · 2019Article
- Phytochemicals from fern species: potential for medicine applications.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2017Article
- Uricase alkaline enzymosomes with enhanced stabilities and anti-hyperuricemia effects induced by favorable microenvironmental changes.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal serum urate levels are recognized as a critical factor in the progression of several chronic diseases. To evaluate the antihyperuricemic effect of Davallia formosana, the inhibitory activities of 15 isolated phytochemicals, including five novel compounds of 6,8-dihydroxychromone-7-C- β -d-glucopyranoside (1), 6,8,3',4'-tetrahydroxyflavanone-7-C- β -d-glucopyranoside (2), 6,8,4'-trihydroxyflavanone-7-C- β -d-glucopyranoside (3), 8-(2-pyrrolidinone-5-yl)-catechin-3-O- β -d-allopyranoside (4), and epiphyllocoumarin-3-O- β -d-allopyranoside (5), were examined against xanthine oxidase (XOD) and in a potassium oxonate-(PTO-) induced acute hyperuricemic mice model. The results indicated that compounds 3 and 5 significantly inhibited XOD activity in vitro and reduced serum uric acid levels in vivo. This is the first report providing new insights into the antihyperuricemic activities of flavonoid glycosides which can possibly be developed into potential hypouricemic agents.
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Registered trials
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