Evidence map›Paper›PMID 24883054›Full record

ArticleInterventional neurology2014

Stenting and angioplasty of small cerebral arteries in symptomatic intracranial atherosclerotic disease.

Osama O Zaidat, Junaid Kalia, Emad Nourollah-Zadeh, Alicia Castonguay, Marc Lazzaro, John Lynch, Brian-Fred Fitzsimmons

Open access · greenAbstract read
In one paragraph

Article in Interventional neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Undersized angioplasty and stenting of symptomatic intracranial tight stenosis with Enterprise: Evaluation of clinical and vascular outcome.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Osama O ZaidatDepartment of Neurology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin ; Department of Neurosurgery, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin ; Department of Radiology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin.
Junaid KaliaDepartment of Neurology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin.
Emad Nourollah-ZadehDepartment of Neurology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin.
Alicia CastonguayDepartment of Neurology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin.
Marc LazzaroDepartment of Neurology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin ; Department of Neurosurgery, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin.
John LynchDepartment of Neurology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin ; Department of Neurosurgery, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin ; Department of Radiology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin.
Brian-Fred FitzsimmonsDepartment of Neurology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin ; Department of Neurosurgery, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin ; Department of Radiology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin.
Medical College of Wisconsin · USFroedtert Hospital · US

Funding

Clincal and Translational Science AwardUL1TR000055 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2012 to 2015
$11.3M
The Milwaukee Clinical Site HubU10NS058927 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI AUFDERHEIDE, TOM PAUL · 2007 to 2016
$2.4M
NCATS NIH HHS UL1 TR000055NINDS NIH HHS U10 NS058927
6 · The paper itself

Abstract

backgroundIntracranial atherosclerotic disease (ICAD) is a common cause of stroke with a poor natural history despite medical therapy. Few studies have investigated endovascular therapies for the treatment of symptomatic ICAD in distal intracranial arteries. Here, we present the feasibility and safety of balloon angioplasty with and without stenting in patients with medically refractory small artery symptomatic ICAD.

methodPersonal logs were reviewed to identify patients who were treated for small artery ICAD (stenosis > 50%) using angioplasty ± stenting. Small cerebral arteries were defined by a diameter ≤ 2 mm or any branch distal to a large intracranial vessel (i.e. distal to ICA, M1, A1, Vertebrobasilar trunk). Patient characteristics, clinical manifestations, treatment, hospital course, and follow up data was collected and analyzed.

resultsTen patients (12 arteries) were treated with either primary balloon angioplasty (58.3%) or angioplasty with stenting (41.6 %) with 100% technical success rate. Mean pre-treatment stenosis was 79.9% while mean post-treatment stenosis was 19.0%. There were no major peri-procedural complications including symptomatic intracranial hemorrhage or mortality; three cases were complicated by groin hematoma. Patients were followed for a mean total of 18.6 months with only one symptomatic restenosis which was re-treated successfully. All patients had good functional outcome with a mRS of either 0 (80%) or 1 (20%) on follow up.

conclusionIn our case series, treatment of symptomatic small artery ICAD with angioplasty ± stenting was safe and effective. These interventions should be considered as an alternative treatment for ICAD patients refractory to medical therapy.

Indexed as

angioplastyintracranial atherosclerotic diseasesmall intracranial arteriesstentingWingspan

Identifiers

PMID24883054
PMCPMC4037134
OpenAlexW2046254240

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.