ArticleSleep2014
Severity of obstructive sleep apnea is associated with cardiac troponin I concentrations in a community-based sample: data from the Akershus Sleep Apnea Project.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Effect of positive airway pressure on cardiac troponins in patients with sleep-disordered breathing: A meta-analysis.Clinical cardiology · 2022Pooled it
- Effects of sleep apnea hypopnea syndromes on cardiovascular events: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2022Pooled it
- Article
- Obstructive Sleep Apnoea and Atrial Fibrillation: Current Evidence and Emerging Research Directions.Reviews in cardiovascular medicine · 2026Review
- A proposed model using glycation metrics and circulating biomarkers for the prevention of cardiovascular disease.Frontiers in medicine · 2025Article
- The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients.ERJ open research · 2025Article
- Is COPD the Determinant Factor for Myocardial Injury and Cardiac Wall Stress in OSA Patients?Medicina (Kaunas, Lithuania) · 2023Article
- The impact of sleep disordered breathing on cardiac troponin in acutely decompensated heart failure.Sleep & breathing = Schlaf & Atmung · 2023Article
- Article
- Identification of Potential Diagnostic Biomarkers From Circulating Cells During the Course of Sleep Deprivation-Related Myocardial Infarction Based on Bioinformatics Analyses.Frontiers in cardiovascular medicine · 2022Article
- The impact of obstructive sleep apnoea severity on cardiac structure and injury.Sleep medicine · 2021Article
- Sleep-disordered breathing and left ventricular scar on cardiac magnetic resonance: results of the Multi-Ethnic Study of Atherosclerosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Untreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population; data from the Akershus Sleep Apnea Project.BMC pulmonary medicine · 2018Article
- Article
- Accelerated tumor growth under intermittent hypoxia is associated with hypoxia-inducible factor-1-dependent adaptive responses to hypoxia.Oncotarget · 2017Article
- Biomarkers in Sleep Apnea and Heart Failure.Current heart failure reports · 2017Review
- Biomarkers of cardiovascular injury and stress are associated with increased frequency of ventricular ectopy: a population-based study.BMC cardiovascular disorders · 2016Article
- Sleep apnea in total joint arthroplasty patients and the role for cardiac biomarkers for risk stratification: an exploration of feasibility.Biomarkers in medicine · 2016Review
- Natriuretic Peptide and High-Sensitive Troponin T Concentrations Correlate with Effectiveness of Short-Term CPAP in Patients with Obstructive Sleep Apnea and Coronary Artery Disease.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPrevious community-based studies have failed to demonstrate an independent association between OSA and circulating cardiac troponin concentrations, a marker of myocardial injury. However, these studies have used troponin assays with modest analytic sensitivity to detect low-level, chronic increments in troponin levels. Using a highly sensitive troponin I (hs-TnI) assay, we tested the hypothesis that the severity of OSA is associated with myocardial injury independently of comorbidities.
designCross-sectional study.
settingCommunity-based.
participants514 subjects (54% men, age 48 ± 11 y [mean ± SD]).
interventionsN/A. MEASUREMENTS AND
resultshs-TnI concentrations were measured in fasting morning blood samples and 318 participants (62%) had hs-TnI concentration above the limit of detection ([LoD] 1.2 ng/L). The severity of OSA, expressed as the apnea-hypopnea index (AHI) and nocturnal hypoxemia, was assessed by in-hospital polysomnography. After adjustment for age, gender, estimated creatinine clearance, history of coronary artery disease and hypertension, smoking, diabetes mellitus, systolic blood pressure, heart rate, body mass index, left ventricular hypertrophy, and cholesterol ratio in multivariate linear regression models, higher AHI (standardized β = 0.12, P = 0.006), lower mean SpO2 (β = -0.13, P = 0.012) and higher percentage of total sleep time with SpO2 < 90% (β = 0.12, P = 0.011) were all associated with higher hs-TnI levels in separate models. Additional analyses with hs-TnI categorized in tertiles or using a different strategy for persons with hs-TnI levels below the LoD did not change the results.
conclusionIncreased obstructive sleep apnea (OSA) severity is independently associated with higher concentrations of hs-TnI, suggesting that frequent apneas or hypoxemia in OSA may cause low-grade myocardial injury.
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Registered trials
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