ArticleInternational journal of radiation biology2014
Long-term cognitive effects of human stem cell transplantation in the irradiated brain.
Article in International journal of radiation biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Human neural stem cell-derived extracellular vesicles improve cognitive function following glioma chemoradiation therapy.Cancer letters · 2026Article
- Contrast-enhanced TScientific reports · 2026Article
- C5aR1 Inhibition Alleviates Cranial Radiation-Induced Cognitive Decline.Cancer research · 2026Article
- New Radiobiological Principles for the CNS Arising from Space Radiation Research.Life (Basel, Switzerland) · 2023Article
- Can a comparison of clinical and deep space irradiation scenarios shed light on the radiation response of the brain?The British journal of radiology · 2020Article
- Extracellular Vesicle-Derived miR-124 Resolves Radiation-Induced Brain Injury.Cancer research · 2020Article
- Stem-Cell Therapy as a Potential Strategy for Radiation-Induced Brain Injury.Stem cell reviews and reports · 2020Review
- Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain.Stem cells translational medicine · 2020Article
- miRNA-based therapeutic potential of stem cell-derived extracellular vesicles: a safe cell-free treatment to ameliorate radiation-induced brain injury.International journal of radiation biology · 2019Review
- Exposure to Ionizing Radiation Causes Endoplasmic Reticulum Stress in the Mouse Hippocampus.Radiation research · 2018Article
- Stem Cell Therapies for the Resolution of Radiation Injury to the Brain.Current stem cell reports · 2017Article
- Cellular Therapies for Treatment of Radiation Injury: Report from a NIH/NIAID and IRSN Workshop.Radiation research · 2017Article
- Cellular Therapies for Treatment of Radiation Injury after a Mass Casualty Incident.Radiation research · 2017Article
- Advances in Monitoring Cell-Based Therapies with Magnetic Resonance Imaging: Future Perspectives.International journal of molecular sciences · 2017Review
- Elimination of microglia improves cognitive function following cranial irradiation.Scientific reports · 2016Article
- A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory: with applications for the evaluation of possible stem cell imaging agents and therapies.Journal of neuro-oncology · 2016Article
- Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction.Frontiers in molecular neuroscience · 2016Article
- Human neural stem cell transplantation provides long-term restoration of neuronal plasticity in the irradiated hippocampus.Cell transplantation · 2015Article
- Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials.Radiation oncology journal · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeRadiotherapy remains a primary treatment modality for the majority of central nervous system tumors, but frequently leads to debilitating cognitive dysfunction. Given the absence of satisfactory solutions to this serious problem, we have used human stem cell therapies to ameliorate radiation-induced cognitive impairment. Here, past studies have been extended to determine whether engrafted cells provide even longer-term benefits to cognition. MATERIALS AND
methodsAthymic nude rats were cranially irradiated (10 Gy) and subjected to intrahippocampal transplantation surgery 2 days later. Human embryonic stem cells (hESC) or human neural stem cells (hNSC) were transplanted, and animals were subjected to cognitive testing on a novel place recognition task 8 months later.
resultsGrafting of hNSC was found to provide long lasting cognitive benefits over an 8-month post-irradiation interval. At this protracted time, hNSC grafting improved behavioral performance on a novel place recognition task compared to irradiated animals not receiving stem cells. Engrafted hESC previously shown to be beneficial following a similar task, 1 and 4 months after irradiation, were not found to provide cognitive benefits at 8 months.
conclusionsOur findings suggest that hNSC transplantation promotes the long-term recovery of the irradiated brain, where intrahippocampal stem cell grafting helps to preserve cognitive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.