ArticleCurrent biology : CB2014
Differential adhesion determines the organization of synaptic fascicles in the Drosophila visual system.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Imprecision in Vision: Lessons From Neural Circuits in the Fly.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Nervous system-wide analysis of allScience advances · 2025Article
- Two distinct mechanisms of Plexin A function in Drosophila optic lobe lamination and morphogenesis.Development (Cambridge, England) · 2024Article
- Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules.Cell reports · 2022Article
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- Neural specification, targeting, and circuit formation during visual system assembly.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.Cell · 2020Review
- Control of Synaptic Specificity by Establishing a Relative Preference for Synaptic Partners.Neuron · 2019Article
- N-Cadherin Orchestrates Self-Organization of Neurons within a Columnar Unit in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Axon Guidance and Collective Cell Migration by Substrate-Derived Attractants.Frontiers in molecular neuroscience · 2019Article
- Ordered arrangement of dendrites within aeLife · 2018Article
- Strategies for assembling columns and layers in the Drosophila visual system.Neural development · 2018Review
- Article
- Regulated Alternative Splicing ofGenetics · 2018Article
- A conserved plan for wiring up the fan-shaped body in the grasshopper and Drosophila.Development genes and evolution · 2017Article
- Micro-connectomics: probing the organization of neuronal networks at the cellular scale.Nature reviews. Neuroscience · 2017Review
- Wiring visual systems: common and divergent mechanisms and principles.Current opinion in neurobiology · 2017Review
- Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
backgroundNeuronal circuits in worms, flies, and mammals are organized so as to minimize wiring length for a functional number of synaptic connections, a phenomenon called wiring optimization. However, the molecular mechanisms that establish optimal wiring during development are unknown. We addressed this question by studying the role of N-cadherin in the development of optimally wired neurite fascicles in the peripheral visual system of Drosophila.
resultsPhotoreceptor axons surround the dendrites of their postsynaptic targets, called lamina cells, within a concentric fascicle called a cartridge. N-cadherin is expressed at higher levels in lamina cells than in photoreceptors, and all genetic manipulations that invert these relative differences displace lamina cells to the periphery and relocate photoreceptor axon terminals into the center.
conclusionsDifferential expression of a single cadherin is both necessary and sufficient to determine cartridge structure because it positions the most-adhesive elements that make the most synapses at the core and the less-adhesive elements that make fewer synapses at the periphery. These results suggest a general model by which differential adhesion can be utilized to determine the relative positions of axons and dendrites to establish optimal wiring.
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