ReviewCanadian journal of psychiatry. Revue canadienne de psychiatrie2014
From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment.
Review in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04179006 (Effects of Nutrients Supplementation in Antidepressant Treated Depressive Disorder Patients), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Nutrients Supplementation in Antidepressant Treated Depressive Disorder Patients
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP.The pharmacogenomics journal · 2020Pooled it
- Polygenic heterogeneity in antidepressant treatment and placebo response.Translational psychiatry · 2022Trial
- Association of DNA methylation in BDNF with escitalopram treatment response in depressed Chinese Han patients.European journal of clinical pharmacology · 2018Trial
- Prediction of long-term treatment response to selective serotonin reuptake inhibitors (SSRIs) using scalp and source loudness dependence of auditory evoked potentials (LDAEP) analysis in patients with major depressive disorder.International journal of molecular sciences · 2015Trial
- Citalopram-induced pathways regulation and tentative treatment-outcome-predicting biomarkers in lymphoblastoid cell lines from depression patients.Translational psychiatry · 2020Article
- Article
- Genotype, phenotype, and medication recommendation agreement among commercial pharmacogenetic-based decision support tools.The pharmacogenomics journal · 2018Article
- Association of Novel ALX4 Gene Polymorphisms with Antidepressant Treatment Response: Findings from the CO-MED Trial.Molecular neuropsychiatry · 2018Article
- [Pharmacogenetics in psychiatry: state of the art].Der Nervenarzt · 2018Review
- Heterogeneous stock rats: a model to study the genetics of despair-like behavior in adolescence.Genes, brain, and behavior · 2018Article
- Article
- Precision pharmacotherapy: psychiatry's future direction in preventing, diagnosing, and treating mental disorders.Pharmacogenomics and personalized medicine · 2018Review
- Pharmacogenetics and Imaging-Pharmacogenetics of Antidepressant Response: Towards Translational Strategies.CNS drugs · 2016Review
- TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.The international journal of neuropsychopharmacology · 2016Article
- Article
- Pursuit of the "truth" about mental illness: the significance of findings in neuropsychiatric research, and lessons from the past.Dialogues in clinical neuroscience · 2014Article
- Is there a role for antidepressant and antipsychotic pharmacogenetics in clinical practice in 2014?Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2014Article
- Pharmacogenetics of antipsychotics.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMajor depressive disorder is the most common psychiatric disorder, worldwide, yet response and remission rates are still unsatisfactory. The identification of genetic predictors of antidepressant (AD) response could provide a promising opportunity to improve current AD efficacy through the personalization of treatment. The major steps and findings along this path are reviewed together with their clinical implications and limitations.
methodWe systematically reviewed the literature through MEDLINE and Embase database searches, using any word combination of "antidepressant," "gene," "polymorphism," "pharmacogenetics," "genome-wide association study," "GWAS," "response," and "adverse drug reactions." Experimental works and reviews published until March 2012 were collected and compared.
resultsNumerous genes pertaining to several functional systems were associated with AD response. The more robust findings were found for the following genes: solute carrier family 6 (neurotransmitter transporter), member 4; serotonin receptor 1A and 2A; brain-derived neurotrophic factor; and catechol-O-methyltransferase. Genome-wide association studies (GWASs) provided many top markers, even if none of them reached genome-wide significance.
conclusionsAD pharmacogenetics have not produced any knowledge applicable to routine clinical practice yet, as results were mainly inconsistent across studies. Despite this, the rising awareness about methodological deficits of past studies could allow for the identication of more suitable strategies, such as the integration of the GWAS approach with the candidate gene approach, and innovative methodologies, such as pathway analysis and study of depressive endophenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.