Evidence map›Paper›PMID 24880737›Full record

ReviewAdvances in genetics2014

Unisexual reproduction.

Kevin C Roach, Marianna Feretzaki, Sheng Sun, Joseph Heitman

Abstract readReview
In one paragraph

Review in Advances in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  2. Article
  3. On the evolution of variation in sexual reproduction through the prism of eukaryotic microbes.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Review
  4. Article
  5. Article
  6. Genetic Networks That Govern Sexual Reproduction in the Pezizomycotina.Microbiology and molecular biology reviews : MMBR · 2021
    Review
  7. Article
  8. Mating Systems in True Morels (Microbiology and molecular biology reviews : MMBR · 2021
    Review
  9. Article
  10. Article
  11. Genetic improvement in3 Biotech · 2019
    Review
  12. Article
  13. Article
  14. Article
  15. Fungal Sex: The Basidiomycota.Microbiology spectrum · 2017
    Review
  16. Fungi that Infect Humans.Microbiology spectrum · 2017
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kevin C RoachDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Marianna FeretzakiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Sheng SunDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

Funding

Tri-Institutional Molecular Mycology and Pathogenesis Training ProgramT32AI052080 · NIAID · DUKE UNIVERSITY · PI ANDREW ALSPAUGH, JOSEPH HEITMAN · 2003 to 2026
$8.7M
Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
NIAID NIH HHS AI52080NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI50113-10NIAID NIH HHS R37 AI039115NIAID NIH HHS R37 AI39115-16NIAID NIH HHS T32 AI052080
6 · The paper itself

Abstract

Sexual reproduction is ubiquitous throughout the eukaryotic kingdom, but the capacity of pathogenic fungi to undergo sexual reproduction has been a matter of intense debate. Pathogenic fungi maintained a complement of conserved meiotic genes but the populations appeared to be clonally derived. This debate was resolved first with the discovery of an extant sexual cycle and then unisexual reproduction. Unisexual reproduction is a distinct form of homothallism that dispenses with the requirement for an opposite mating type. Pathogenic and nonpathogenic fungi previously thought to be asexual are able to undergo robust unisexual reproduction. We review here recent advances in our understanding of the genetic and molecular basis of unisexual reproduction throughout fungi and the impact of unisex on the ecology and genomic evolution of fungal species.

Indexed as

Cryptococcus neoformansFungiGenes, Mating Type, FungalReproduction, AsexualCandida albicansCryptococcus neoformansFungal meiosisHeterothallicHomothallicMating typeNeurosporaPathogenicityUnisexual reproduction

Identifiers

PMID24880737
PMCPMC9036533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.