Evidence map›Paper›PMID 24880614›Full record

ArticleNature medicine2014

Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization.

Sandra C Bernard, Nandi Simpson, Olivier Join-Lambert, Christian Federici, Marie-Pierre Laran-Chich, Nawal Maïssa, Haniaa Bouzinba-Ségard, Philippe C Morand, Fabrice Chretien, Saïd Taouji and 10 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 160 citations in OpenAlex.

  1. The truncated major pilin subunit SBP2' contributes toApplied and environmental microbiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Frontiers in cellular and infection microbiology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 1 country.

Sandra C Bernard1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [4] Université Paris Diderot, Paris, France. [5].
Nandi Simpson1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [4] [5].
Olivier Join-Lambert1] INSERM, U1151, Institut Necker Enfants Malades, Paris, France. [2] CNRS, UMR8253, Paris, France. [3] Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [4] Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Paris, France.
Christian Federici1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Marie-Pierre Laran-Chich1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Nawal Maïssa1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Haniaa Bouzinba-Ségard1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Philippe C Morand1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Fabrice Chretien1] Unité Histopathologie Humaine et Modèles Animaux, Institut Pasteur, Paris, France. [2] Faculté de Médecine, Université Versailles Saint-Quentin-en-Yvelines, Versailles, France. [3] Assistance Publique-Hôpitaux de Paris, Hôpital Raymond Poincaré, Paris, France.
Saïd TaoujiBMYscreen, INSERM U1053, Université de Bordeaux, Bordeaux, France.
Eric ChevetBMYscreen, INSERM U1053, Université de Bordeaux, Bordeaux, France.
Sébastien Janel1] Cellular Microbiology of Infectious Pathogens, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Lille, France. [2] CNRS UM8204, Lille, France. [3] INSERM U1019, Lille, France. [4] BioImaging Center Lille (BICeL), Université Lille Nord de France, Lille, France.
Frank Lafont1] Cellular Microbiology of Infectious Pathogens, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Lille, France. [2] CNRS UM8204, Lille, France. [3] INSERM U1019, Lille, France. [4] BioImaging Center Lille (BICeL), Université Lille Nord de France, Lille, France.
Mathieu Coureuil1] INSERM, U1151, Institut Necker Enfants Malades, Paris, France. [2] CNRS, UMR8253, Paris, France. [3] Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Audrey Segura1] INSERM, U1151, Institut Necker Enfants Malades, Paris, France. [2] CNRS, UMR8253, Paris, France. [3] Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Florence Niedergang1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Stefano Marullo1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Pierre-Olivier Couraud1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Xavier Nassif1] INSERM, U1151, Institut Necker Enfants Malades, Paris, France. [2] CNRS, UMR8253, Paris, France. [3] Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [4] Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Paris, France.
Sandrine Bourdoulous1] INSERM, U1016, Institut Cochin, Paris, France. [2] CNRS, UMR8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Inserm · FRCentre National de la Recherche Scientifique · FRInstitut Cochin · FRInstitut Necker Enfants Malades · FRCenter for Infection and Immunity of Lille · FRInstitut Pasteur · FRInstitut Pasteur de Lille · FRUniversité de Bordeaux · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neisseria meningitidis is a cause of meningitis epidemics worldwide and of rapidly progressing fatal septic shock. A crucial step in the pathogenesis of invasive meningococcal infections is the adhesion of bloodborne meningococci to both peripheral and brain endothelia, leading to major vascular dysfunction. Initial adhesion of pathogenic strains to endothelial cells relies on meningococcal type IV pili, but the endothelial receptor for bacterial adhesion remains unknown. Here, we report that the immunoglobulin superfamily member CD147 (also called extracellular matrix metalloproteinase inducer (EMMPRIN) or Basigin) is a critical host receptor for the meningococcal pilus components PilE and PilV. Interfering with this interaction potently inhibited the primary attachment of meningococci to human endothelial cells in vitro and prevented colonization of vessels in human brain tissue explants ex vivo and in humanized mice in vivo. These findings establish the molecular events by which meningococci target human endothelia, and they open new perspectives for treatment and prevention of meningococcus-induced vascular dysfunctions.

Indexed as

Bacterial AdhesionBasiginBlood VesselsFimbriae, BacterialHumansNeisseria meningitidisBasigin

Identifiers

PMID24880614
PMCPMC7095922
OpenAlexW1994159005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.