ArticleMolecular and cellular biochemistry2014
miR-1246 releases RTKN2-dependent resistance to UVB-induced apoptosis in HaCaT cells.
Article in Molecular and cellular biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Histone modification and non-coding RNAs in skin aging: emerging therapeutic avenues.Open life sciences · 2025Review
- Article
- Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin.International journal of molecular sciences · 2021Review
- MicroRNA-1246 by Targeting AXIN2 and GSK-3β Overcomes Drug Resistance and Induces Apoptosis in Chemo-resistant Leukemia Cells.Journal of Cancer · 2021Article
- The Role of microRNAs in Organismal and Skin Aging.International journal of molecular sciences · 2020Review
- The origin of exosomal miR-1246 in human cancer cells.RNA biology · 2019Article
- MicroRNA Expression in Cutaneous Lupus: A New Window to Understand Its Pathogenesis.Mediators of inflammation · 2019Article
- Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells.Bioscience reports · 2018Article
- Neural stem cell derived extracellular vesicles: Attributes and prospects for treating neurodegenerative disorders.EBioMedicine · 2018Review
- MiR-1246 is upregulated and regulates lung cell apoptosis during heat stress in feedlot cattle.Cell stress & chaperones · 2018Article
- Long non-coding RNA HOTAIR promotes UVB-induced apoptosis and inflammatory injury by up-regulation of PKR in keratinocytes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation.Molecular neurobiology · 2017Review
- microRNA-1246 mediates lipopolysaccharide-induced pulmonary endothelial cell apoptosis and acute lung injury by targeting angiotensin-converting enzyme 2.American journal of translational research · 2017Article
- Hsa-miR-520d-5p promotes survival in human dermal fibroblasts exposed to a lethal dose of UV irradiation.NPJ aging and mechanisms of disease · 2016Article
- Investigation of Content, Stoichiometry and Transfer of miRNA from Human Neural Stem Cell Line Derived Exosomes.PloS one · 2016Article
- MiR-664 Protects Against UVB Radiation-Induced HaCaT Cell Damage via Downregulating ARMC8.Dose-response : a publication of International Hormesis SocietyArticle
- MicroRNA-145 attenuates IL-6-induced enhancements of sensitivity to UVB irradiation by suppressing MyD88 in HaCaT cells.International journal of immunopathology and pharmacologyArticle
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs are a kind of small non-coding RNAs that play important roles in various biological processes such as cell proliferation, differentiation, and apoptosis. Cellular responses to UV-induced apoptosis have been suggested to be regulated by microRNAs at the posttranscriptional level, while the detailed mechanisms underlying this process remain unclear. Our aim in this study was to investigate the effects of miR-1246 in UVB-induced apoptosis and to identify the functional targets of miR-1246 in keratinocyte HaCaT cells. The expression of miR-1246 and apoptotic genes in HaCaT cells experiencing UVB stress was determined using quantitative real-time PCR. miR-1246 functions in UVB-induced apoptosis were quantified via fluorescence-activated cell sorter analysis of miR-1246 mimic or inhibitor-transfected cells. Additionally, the regulatory relationship between RTKN2 and miR-1246 was identified by Western blot and luciferase reporter assays. miR-1246 was upregulated accompanying with UVB-irradiated apoptosis in HaCaT cells. Overexpression of miR-1246 promoted UVB-induced apoptosis, while knockdown of miR-1246, using a specific inhibitor, resulted in a significant reduction in UVB-elicited apoptosis. We further demonstrate that miR-1246 negatively regulated the expression of RTKN2 through binding to the 3'-untranslated region of RTKN2 at the posttranscriptional level. Moreover, RTKN2 was observed to be resistant to UVB-induced apoptosis and RTKN2 antagonized the pro-apoptotic effects of miR-1246 during UVB-induced apoptosis in HaCaT cells. These findings suggested that miR-1246 promotes UVB-induced apoptosis by downregulating RTKN2 expression and that UVB-upregulated miR-1246 released RTKN2-dependent resistance to UVB-induced apoptosis by targeting RTKN2 post-transcriptionally in keratinocyte cells.
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