Evidence map›Paper›PMID 24880340›Full record

ArticleNature genetics2014

Identification of erythroferrone as an erythroid regulator of iron metabolism.

Léon Kautz, Grace Jung, Erika V Valore, Stefano Rivella, Elizabeta Nemeth, Tomas Ganz

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 540 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
540citing papers in PubMed, 5 pooled it
62.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

540 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,073 citations in OpenAlex.

  1. Recent Advances in Research on Iron Metabolism, Ferritin, and Hepcidin.International journal of molecular sciences · 2026
    Pooled it
  2. Pooled it
  3. Ferroptosis and Senescence: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
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  14. Review
  15. The N6-methyladenosine (mBritish journal of haematology · 2026
    Article
  16. Review
  17. Review
  18. Thalassaemia.Nature reviews. Disease primers · 2026
    Review
  19. Review
  20. Article

480 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Léon KautzDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Grace JungDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Erika V ValoreDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Stefano Rivella1] Department of Pediatrics, Division of Hematology-Oncology, Weill Cornell Medical College, New York, New York, USA. [2] Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York, USA.
Elizabeta NemethDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Tomas Ganz1] Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. [2] Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · USCornell University · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Regulatory Role of Transferrin in Erythropoiesis and Iron MetabolismR01DK095112 · NIDDK · SAINT LOUIS UNIVERSITY · PI Robert E Fleming, Yelena Ginzburg · 2012 to 2026
$5.4M
Hepcidin therapy for iron overload and hematologic disordersR01DK090554 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI RIVELLA, STEFANO · 2010 to 2021
$5.2M
The role of erythroferrone in iron homeostasis and in iron-loading anemiasR01DK065029 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GANZ, TOMAS · 2004 to 2017
$4.9M
NCI NIH HHS CA-16042NCI NIH HHS P30 CA016042NCI NIH HHS P30-CA-016042NIAID NIH HHS AI-28697NIAID NIH HHS P30 AI028697NIDDK NIH HHS 5R01-DK-095112NIDDK NIH HHS P30 DK041301NIDDK NIH HHS P30-DK-041301NIDDK NIH HHS R01 DK065029NIDDK NIH HHS R01-DK-065029NIDDK NIH HHS R01 DK090554NIDDK NIH HHS R01-DK-090554
6 · The paper itself

Abstract

Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores. We identified a new hormone, erythroferrone (ERFE), that mediates hepcidin suppression during stress erythropoiesis. ERFE is produced by erythroblasts in response to erythropoietin. ERFE-deficient mice fail to suppress hepcidin rapidly after hemorrhage and exhibit a delay in recovery from blood loss. ERFE expression is greatly increased in Hbb(th3/+) mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease.

Indexed as

AnemiaAnimalsbeta-ThalassemiaBlotting, WesternDisease Models, AnimalEnzyme-Linked Immunosorbent AssayEpoetin AlfaErythropoiesisErythropoietinGene Expression ProfilingHemoglobinsHemorrhageHepcidinsHormonesIronIron OverloadEpoetin AlfaErythropoietinHemoglobinsHepcidinsHormonesIronRecombinant ProteinsRNA, Messenger

Identifiers

PMID24880340
PMCPMC4104984
OpenAlexW2006046265

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.