Evidence map›Paper›PMID 24879974›Full record

ReviewJournal of cardiac failure2014

Loop diuretic resistance in heart failure: resistance etiology-based strategies to restoring diuretic efficacy.

Zachary L Cox, Daniel J Lenihan

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of cardiac failure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04298229 (A Randomized, Open-label Study of Dapagliflozin in Patients With or Without Type 2 Diabetes Admitted With Acute Heart Failure), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04298229 phase3completedstarted 2020, after this paper: background citation

A Randomized, Open-label Study of Dapagliflozin in Patients With or Without Type 2 Diabetes Admitted With Acute Heart Failure

Ran2020Enrolled240Registered outcomes3Posted comparisons0ConditionsDiabetes Mellitus, Type 2, Heart FailureArmsDapagliflozin 10 mg, Protocolized Diuretic Therapy
PMID 27266853PMID 26299229PMID 26041600PMID 25838436PMID 25287144PMID 24585267PMID 24379278PMID 24247300PMID 23356556PMID 23333145PMID 23141816PMID 21732835other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Acute Heart Failure Management.Korean circulation journal · 2018
    Review
  11. Article
  12. [Diuretic resistance and heart failure: between congestion and kidney injury].Archivos peruanos de cardiologia y cirugia cardiovascular
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Zachary L CoxDepartment of Pharmacy Practice, Lipscomb University College of Pharmacy, Nashville, Tennessee; Department of Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: zachary.l.cox@vanderbilt.edu.
Daniel J LenihanDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Lipscomb University · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loop diuretics are a cornerstone of symptom management for nearly all patients with heart failure. Diuretic resistance is a clinical problem with similar presentation despite diverse and multiple etiologies. Although the exact incidence is not known, diuretic resistance occurs frequently and can increase the length of hospitalization. Despite the prevalence of loop diuretic prescription in heart failure and frequency of diuretic resistance, current heart failure guidelines provide nonspecific guidance on strategies to restore diuretic efficacy. Providers are left with many questions regarding the optimum diuretic titration strategy in the setting of diuretic resistance. In light of these highly prevalent uncertainties, we present a case vignette-structured literature review of the mechanisms of diuretic resistance and recommend therapeutic strategies based on the resistance etiology to improve diuretic response in acute decompensated heart failure.

Indexed as

Practice Guidelines as TopicDiureticsDrug ResistanceHeart FailureHumansInfusions, IntravenousSodium Potassium Chloride Symporter InhibitorsDiureticsSodium Potassium Chloride Symporter Inhibitorsacute heart failureCardiology

Identifiers

PMID24879974
OpenAlexW2070093185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.