Evidence map›Paper›PMID 24879949›Full record

SynthesisAmerican journal of ophthalmology2014

Lipids, lipid genes, and incident age-related macular degeneration: the three continent age-related macular degeneration consortium.

Ronald Klein, Chelsea E Myers, Gabriëlle H S Buitendijk, Elena Rochtchina, Xiaoyi Gao, Paulus T V M de Jong, Theru A Sivakumaran, George Burlutsky, Roberta McKean-Cowdin, Albert Hofman and 8 more

Open access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 5 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 5 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Pooled it
  6. Review
  7. CETP Renaissance with Obicetrapib.Current atherosclerosis reports · 2026
    Review
  8. Article
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  12. Role of LIPIN 1 in regulating metabolic homeostasis in the retinal pigment epithelium.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
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  14. Workshop report - interdisciplinary metabolomic epidemiology: the pathway to clinical translation.Metabolomics : Official journal of the Metabolomic Society · 2024
    Article
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

Ronald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address: kleinr@epi.ophth.wisc.edu.
Chelsea E MyersDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Gabriëlle H S BuitendijkDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands.
Elena RochtchinaCentre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia; Clinical Ophthalmology & Eye Health, University of Sydney, Westmead, New South Wales, Australia.
Xiaoyi GaoKeck School of Medicine, University of Southern California, Los Angeles, California.
Paulus T V M de JongNetherlands Institute of Neurosciences, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands; Department of Ophthalmology, Academic Medical Center, Amsterdam, Netherlands; Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands.
Theru A SivakumaranDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio.
George BurlutskyCentre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia; Clinical Ophthalmology & Eye Health, University of Sydney, Westmead, New South Wales, Australia.
Roberta McKean-CowdinKeck School of Medicine, University of Southern California, Los Angeles, California; Department of Preventive Medicine, University of Southern California, Los Angeles, California.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands; Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, the Hague, Netherlands.
Sudha K IyengarDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio.
Kristine E LeeDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Bruno H StrickerDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
Johannes R VingerlingDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands.
Paul MitchellClinical Ophthalmology & Eye Health, University of Sydney, Westmead, New South Wales, Australia.
Barbara E K KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Caroline C W KlaverDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands.
Jie Jin WangCentre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia.
Erasmus MC · NLThe University of Sydney · AUUniversity of Southern California · USCase Western Reserve University · USCincinnati Children's Hospital Medical Center · USRoyal Netherlands Academy of Arts and Sciences · NLUniversity of Wisconsin–Madison · US

Funding

THE EPIDEMIOLOGY OF AGE-RELATED OCULAR DISEASEU10EY006594 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, RONALD · 1987 to 2018
$17.3M
NEI NIH HHS EY06594NEI NIH HHS U10 EY006594Wellcome Trust
6 · The paper itself

Abstract

purposeTo describe associations of serum lipid levels and lipid pathway genes to the incidence of age-related macular degeneration (AMD).

designMeta-analysis.

methodssetting: Three population-based cohorts. population: A total of 6950 participants from the Beaver Dam Eye Study (BDES), Blue Mountains Eye Study (BMES), and Rotterdam Study (RS). observation procedures: Participants were followed over 20 years and examined at 5-year intervals. Hazard ratios associated with lipid levels per standard deviation above the mean or associated with each additional risk allele for each lipid pathway gene were calculated using random-effects inverse-weighted meta-analysis models, adjusting for known AMD risk factors. main outcome measures: Incidence of AMD.

resultsThe average 5-year incidences of early AMD were 8.1%, 15.1%, and 13.0% in the BDES, BMES, and RS, respectively. Substantial heterogeneity in the effect of cholesterol and lipid pathway genes on the incidence and progression of AMD was evident when the data from the 3 studies were combined in meta-analysis. After correction for multiple comparisons, we did not find a statistically significant association between any of the cholesterol measures, statin use, or serum lipid genes and any of the AMD outcomes in the meta-analysis.

conclusionIn a meta-analysis, there were no associations of cholesterol measures, history of statin use, or lipid pathway genes to the incidence and progression of AMD. These findings add to inconsistencies in earlier reports from our studies and others showing weak associations, no associations, or inverse associations of high-density lipoprotein cholesterol and total cholesterol with AMD.

Indexed as

Macular DegenerationDisease ProgressionGlobal HealthHumansIncidenceLipid MetabolismLipidsRisk FactorsLipids

Identifiers

PMID24879949
PMCPMC4138281
OpenAlexW2068484239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.