Evidence map›Paper›PMID 24879752›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2015

Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

Rafal Rygula, Hannah F Clarke, Rudolf N Cardinal, Gemma J Cockcroft, Jing Xia, Jeff W Dalley, Trevor W Robbins, Angela C Roberts

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 88 citations in OpenAlex.

  1. Trial
  2. Chronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: a double-blind, placebo-controlled semi-randomised study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  9. Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  10. Article
  11. Article
  12. Article
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  15. Elevated levels of serotonin 5-HTEuropean archives of psychiatry and clinical neuroscience · 2023
    Article
  16. Article
  17. Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  18. Prefrontal cortex and depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Rafal RygulaDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK Current Address: Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neurobiology and Drug Development, Institute of Pharmacology Polish Academy of Sciences, ul Smetna 12, 31-343 Krakow, Poland.
Hannah F ClarkeBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Rudolf N CardinalBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Cambridge CB2 0QQ, UK Liaison Psychiatry Service, Cambridgeshire and Peterborough NHS Foundation Trust, Box 190, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Gemma J CockcroftDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
Jing XiaDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
Jeff W DalleyDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
Trevor W RobbinsDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
Angela C RobertsBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
University of Cambridge · GBAddenbrooke's Hospital · GBMaj Institute of Pharmacology · PL

Funding

Medical Research Council G0001354Medical Research Council G0901884Medical Research Council G1000183Medical Research Council G1000183BMedical Research Council MR/J012084/1Wellcome Trust 089589/Z/09/ZWellcome Trust 093875Wellcome Trust 104631
6 · The paper itself

Abstract

Understanding the role of serotonin (or 5-hydroxytryptamine, 5-HT) in aversive processing has been hampered by the contradictory findings, across studies, of increased sensitivity to punishment in terms of subsequent response choice but decreased sensitivity to punishment-induced response suppression following gross depletion of central 5-HT. To address this apparent discrepancy, the present study determined whether both effects could be found in the same animals by performing localized 5-HT depletions in the amygdala or orbitofrontal cortex (OFC) of a New World monkey, the common marmoset. 5-HT depletion in the amygdala impaired response choice on a probabilistic visual discrimination task by increasing the effectiveness of misleading, or false, punishment and reward, and decreased response suppression in a variable interval test of punishment sensitivity that employed the same reward and punisher. 5-HT depletion in the OFC also disrupted probabilistic discrimination learning and decreased response suppression. Computational modeling of behavior on the discrimination task showed that the lesions reduced reinforcement sensitivity. A novel, unitary account of the findings in terms of the causal role of 5-HT in the anticipation of both negative and positive motivational outcomes is proposed and discussed in relation to current theories of 5-HT function and our understanding of mood and anxiety disorders.

Indexed as

PunishmentReward5,7-DihydroxytryptamineAmygdalaAnalysis of VarianceAnimalsCallithrixDiscrimination, PsychologicalFemaleMaleMotivationPhotic StimulationPrefrontal CortexProbabilityRecognition, PsychologyRetention, Psychology5,7-DihydroxytryptamineSerotoninSerotonin Agentsamygdalamarmosetorbitofrontal cortexprobabilistic reversal learning

Identifiers

PMID24879752
PMCPMC4537445
OpenAlexW2154966614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.