Evidence map›Paper›PMID 24879628›Full record

ArticleAIDS and behavior2015

Correlation between use of antiretroviral adherence devices by HIV-infected youth and plasma HIV RNA and self-reported adherence.

Parya Saberi, Kenneth Mayer, Eric Vittinghoff, Sylvie Naar-King, Adolescent Medicine Trials Network for HIV/AIDS Interventions

Abstract readMulticenter Study
In one paragraph

Article in AIDS and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  9. Article
  10. HIV Continuum of Care for Youth in the United States.Journal of acquired immune deficiency syndromes (1999) · 2018
    Article
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Parya SaberiDepartment of Medicine, University of California, UCSF Box 0886, 50 Beale St., Suite 1300, San Francisco, CA, 94105, USA, parya.saberi@ucsf.edu.
Kenneth Mayer
Eric Vittinghoff
Sylvie Naar-King
Adolescent Medicine Trials Network for HIV/AIDS Interventions

Funding

Adol. Medicine Trials Network for HIV/AIDS InterventionsU01HD040474 · NICHD · WESTAT, INC. · PI HARRIS, DONALD ROBERT · 2001 to 2016
$114.4M
LEADERSHIP GROUP FOR ADOLESCENT MEDICINE TRIALS NETWORKU01HD040533 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILSON, CRAIG M · 2001 to 2016
$76.4M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Technology-based adaptive treatment strategies for antiretroviral adherenceK23MH097649 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SABERI, PARYA · 2012 to 2016
$890k
NCATS NIH HHS UL1 TR001082NICHD NIH HHS U01 HD 040474NICHD NIH HHS U01 HD040474NICHD NIH HHS U01 HD 040533NICHD NIH HHS U01 HD040533NIMH NIH HHS K23 MH097649NIMH NIH HHS K23MH097649
6 · The paper itself

Abstract

Our objective was to investigate antiretroviral adherence device use by HIV-infected youth and assess associations of device use with viral suppression and self-reported adherence. This cross-sectional, multisite, clinic-based study included data from 1,317 HIV-infected individuals 12-24 years of age that were prescribed antiretroviral therapy. Mean adherence in the past 7 days was 86.1 % and 50.5 % had an undetectable HIV RNA. Pillbox was the most commonly endorsed device. No specific device was independently associated with higher odds of 100 % adherence. Paradoxically, having an undetectable HIV RNA was inversely associated with use of adherence devices (OR 0.80; p = 0.04); however, among those with <100 % adherence, higher adherence was associated with use of one or more adherence devices (coefficient = 7.32; p = 0.003). Our data suggest that adolescents who experienced virologic failure often used adherence devices which may not have been sufficiently effective in optimizing adherence. Therefore, other tailored adherence-enhancing methods need to be considered to maximize virologic suppression and decrease drug resistance and HIV transmission.

Indexed as

Drug MonitoringAdolescentAdolescent BehaviorAnti-Retroviral AgentsCD4 Lymphocyte CountChildCross-Sectional StudiesFemaleHealth Knowledge, Attitudes, PracticeHIV InfectionsHumansMaleMedication AdherenceMedication SystemsReminder SystemsSelf AdministrationAnti-Retroviral Agents

Identifiers

PMID24879628
PMCPMC4250439

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.