ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2014
A multicenter prospective study of infections related morbidity and mortality in cirrhosis of liver.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- An Epidemiological Meta-Analysis on the Worldwide Prevalence, Resistance, and Outcomes of Spontaneous Bacterial Peritonitis in Cirrhosis.Frontiers in medicine · 2021Pooled it
- Lung Microbiome Diversity, Infection Dynamics, and Microbe-Mediated Cross-Protection.MicrobiologyOpen · 2026Review
- Global Prevalence, Temporal Trends, and Associated Mortality of Bacterial Infections in Patients with Liver Cirrhosis: A Meta-analysis.Journal of clinical and translational hepatology · 2025Article
- Characteristics and Related Factors of Bacterial Infection Among Patients With Cirrhosis.Materia socio-medica · 2024Article
- Fungal Infection in Acutely Decompensated Cirrhosis Patients: Value of Model for End-Stage Liver Disease Score.Gastroenterology research · 2020Article
- Predictors of immediate and short-term mortality in spontaneous bacterial peritonitis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Observational
- Clinical audit to determine efficacy of daily infusion of low dose of 20% albumin in combination with antibiotics in patients with spontaneous bacterial peritonitis.Clinical and experimental hepatology · 2019Article
- Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis.Internal and emergency medicine · 2019Observational
- Risk factors predicting nosocomial, healthcare-associated and community-acquired infection in spontaneous bacterial peritonitis and survival outcome.Clinical and experimental hepatology · 2019Article
- Morbidity and mortality of infections in the cirrhotic patients: a US population-based study.Gastroenterology and hepatology from bed to bench · 2019Article
- Prevalence and Impact of Bacterial Infections in Children With Liver Disease-A Prospective Study.Journal of clinical and experimental hepatology · 2018Article
- An Insight into Antibiotic Resistance to Bacterial Infection in Chronic Liver Disease.Journal of clinical and experimental hepatology · 2017Article
- Current Scenario of Hepatitis B and Its Treatment in India.Journal of clinical and translational hepatology · 2017Review
- Characteristics of infection and its impact on short-term outcome in patients with acute-on-chronic liver failure.Medicine · 2017Article
- The prevalence and impact of brucellosis in patients with hepatitis delta virus infection: inside theArchives of medical science : AMS · 2017Article
- Characterization of Polymyxin B Biodistribution and Disposition in an Animal Model.Antimicrobial agents and chemotherapy · 2016Article
- PREVALENCE OF BACTERIAL RESISTANCE IN HOSPITALIZED CIRRHOTIC PATIENTS IN SOUTHERN BRAZIL: A NEW CHALLENGE.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Observational
- Etiological Spectrum of Cirrhosis in India: A Systematic Review and Meta-analysis.Journal of clinical and experimental hepatologyArticle
- A Study of Impact of Fixed-Dose Albumin Infusion on Outcome in Patients With Cirrhosis and Infection: A Randomized Open-label Clinical Trial.Journal of clinical and experimental hepatologyArticle
- Overview of Complications in Cirrhosis.Journal of clinical and experimental hepatologyReview
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsInfections are a common and serious complication among patients with cirrhosis. We assessed the epidemiology, risk factors, and clinical consequences of bacterial infections in cirrhotic patients.
methodsIn this multicenter prospective study, all patients with cirrhosis of liver with different infections were analyzed. Infections were classified as community-acquired (CA), healthcare-associated (HCA), or hospital-acquired (HA). Site of infection and characteristics of bacteria were recorded; effect on liver function and 30-day survival were evaluated.
resultsOne hundred and six out of 420 (25 %) patients with cirrhosis of liver had infection. Infection rate among indoor patients was 37.5 % (92/245) and among outdoor patients was 8 % (14/175). Out of 106 patients, CA, HCA, and HA were seen in 19.8 %, 50 %, and 30.2 %, respectively. Spontaneous bacterial peritonitis (31.1 %), urinary tract infections (22.6 %), and pneumonia and cellulitis (11.3 % each) were common infections. Gram-negative bacteria (54 %) were more common than Gram-positive cocci (46 %). Multidrug resistant (MDR) organisms were seen in 41.7 % of patients. Most of the MDR organisms were seen in HCA and HA patients. The degree of liver impairment was significantly more severe in patients with infection. Independent predictor of infection was high Child-Turcott-Pugh (CTP) class (p = 0.006, Child B vs. A (odds ratio (OR) 3.04 95 % CI = 1.63 to 5.68) and Child C vs. A (OR 4.17 95 % CI = 2.12 to 8.19). Overall in-hospital mortality was 7.6 %. Patients with infection had increased mortality at 30-day follow up compared to those without infection (23.5 % vs. 2.2 %; p<0.001).
conclusionsInfections are one of the important causes of morbidity and mortality in patients with cirrhosis of liver. The most frequent infections are HCA and HA. Infection predisposes to deterioration of liver function and increases mortality. Cirrhotic patients should be monitored closely for infections especially those with Child class B and C.
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