ArticleMolecules (Basel, Switzerland)2014
Antioxidant and antiproliferative activities of methanolic extract from a neglected agricultural product: corn cobs.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Leaves from banana (Musa nana) and maize (Zea mays) have no phyto-prophylactic effects on the susceptibility of grass carp (Ctenopharyngodon idella) to Aeromonas hydrophila infection.BMC veterinary research · 2017Trial
- Potential of Corncob Extract on the Expression of Ki-67 and Caspase3 in Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Development of the Antioxidant Property of Seagrass Extract-Based Hydrogel for Dental Application.Cureus · 2024Article
- Sustainable Isolation of Bioactive Compounds and Proteins from Plant-Based Food (and Byproducts).Plants (Basel, Switzerland) · 2023Review
- Optimization of Polyphenols' Recovery from Purple Corn Cobs Assisted by Infrared Technology and Use of Extracted Anthocyanins as a Natural Colorant in Pickled Turnip.Molecules (Basel, Switzerland) · 2022Article
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- Gibberellic acids promote growth and exopolysaccharide production in Tetraselmis suecica under reciprocal nitrogen concentration: an assessment on antioxidant properties and nutrient removal efficacy of immobilized iron-magnetic nanoparticles.Archives of microbiology · 2021Article
- Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential.Marine drugs · 2021Article
- TanP: A Multifunctional Anionic Peptide FromFrontiers in molecular biosciences · 2021Article
- In Vitro and In Vivo Antioxidant Activity ofBiomolecules · 2020Article
- Gallic Acid-Chitosan Conjugate Inhibits the Formation of Calcium Oxalate Crystals.Molecules (Basel, Switzerland) · 2019Article
- Article
- Isolation, Characterization and Bioactivities of an Extracellular Polysaccharide Produced from Streptomyces sp. MOE6.Molecules (Basel, Switzerland) · 2017Article
- Baccharis trimera (Less.) DC Exhibits an Anti-Adipogenic Effect by Inhibiting the Expression of Proteins Involved in Adipocyte Differentiation.Molecules (Basel, Switzerland) · 2017Article
- Therapeutic properties in Tunisian hot springs: first evidence of phenolic compounds in the cyanobacterium Leptolyngbya sp. biomass, capsular polysaccharides and releasing polysaccharides.BMC complementary and alternative medicine · 2016Article
- Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential.International journal of molecular sciences · 2016Article
- Partial characterization and antioxidant and antiproliferative activities of the aqueous extracellular polysaccharides from the thermophilic microalgae Graesiella sp.BMC complementary and alternative medicine · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neglected agricultural products (NAPs) are defined as discarded material in agricultural production. Corn cobs are a major waste of agriculture maize. Here, a methanolic extract from corn cobs (MEC) was obtained. MEC contains phenolic compounds, protein, carbohydrates (1.4:0.001:0.001). We evaluated the in vitro and in vivo antioxidant potential of MEC. Furthermore, its antiproliferative property against tumor cells was assessed through MTT assays and proteins related to apoptosis in tumor cells were examined by western blot. MEC showed no hydroxyl radical scavenger capacity, but it showed antioxidant activity in Total Antioxidant Capacity and DPPH scavenger ability assays. MEC showed higher Reducing Power than ascorbic acid and exhibited high Superoxide Scavenging activity. In tumor cell culture, MEC increased catalase, metallothionein and superoxide dismutase expression in accordance with the antioxidant tests. In vivo antioxidant test, MEC restored SOD and CAT, decreased malondialdehyde activities and showed high Trolox Equivalent Antioxidant Capacity in animals treated with CCl4. Furthermore, MEC decreased HeLa cells viability by apoptosis due an increase of Bax/Bcl-2 ratio, caspase 3 active. Protein kinase C expression increased was also detected in treated tumor cells. Thus, our findings pointed out the biotechnological potential of corn cobs as a source of molecules with pharmacological activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.