ArticleInternational journal of molecular sciences2014
New coumarins and anti-inflammatory constituents from the fruits of Cnidium monnieri.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
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- Anti-Melanogenic Effects ofPlants (Basel, Switzerland) · 2024Article
- Vasorelaxant and Blood Pressure-Lowering Effects ofInternational journal of molecular sciences · 2024Article
- She-Chuang-Si-Wu-Tang Alleviates Inflammation and Itching Symptoms in a Psoriasis Mouse Model by Regulating the Th17/IL-17 Axis via the STAT3/MAPK Pathways.Journal of inflammation research · 2024Article
- Chemical Constituents from the Roots ofPharmaceutics · 2023Article
- Origin, evolution, breeding, and omics of Apiaceae: a family of vegetables and medicinal plants.Horticulture research · 2022Article
- Preliminary Study on Antifungal Mechanism of Aqueous Extract ofFrontiers in microbiology · 2021Article
- Phytochemistry, Ethnopharmacology, Pharmacokinetics and Toxicology ofInternational journal of molecular sciences · 2020Review
- Antiviral effect of compounds derived from the seeds of Mammea americana and Tabernaemontana cymosa on Dengue and Chikungunya virus infections.BMC complementary and alternative medicine · 2017Article
- Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives.International immunopharmacology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fruit of Cnidium monnieri is commercially used as healthcare products for the improvement of impotence and skin diseases. Three new coumarins, 3'-O-methylmurraol (1), rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2), and (1'S,2'S)-1'-O-methylvaginol (3), have been isolated from the fruits of C. monnieri, together with 14 known compounds (4-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4-12, and 14-17 exhibited inhibition (IC50 ≤ 7.31 µg/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 7, 9-11, 15, and 17 inhibited fMLP/CB-induced elastase release with IC50 values ≤7.83 µg/mL. This investigation reveals that bioactive isolates (especially 6, 7, 14, and 17) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.
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