ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
Asystole following regadenoson infusion in stable outpatients.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Incidence of atrioventricular block with vasodilator stress SPECT: A meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Pooled it
- Regadenoson provides perfusion results comparable to adenosine in heterogeneous patient populations: a quantitative analysis from the ADVANCE MPI trials.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Trial
- Safety and tolerability of pharmacologic stress with the selective AClinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Advanced Heart Block and Asystole After Regadenoson Infusion: When Cautionary Tales Become Reality.Cureus · 2023Article
- Asystole following Regadenoson administration: Review of literature, risk factors and management.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Review
- Selective Adenosine A2A Agonists May Change Myocardial Perfusion Imaging.Annals of nuclear cardiology · 2021Review
- Adverse effects associated with regadenoson myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Regadenoson-induced complete heart block and asystole: A real possibility nuclear laboratories should be aware of.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Vasodilator stress agents for myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Safety of vasodilator stress myocardial perfusion imaging in patients with elevated cardiac biomarkers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Choosing exercise or pharmacologic stress imaging, or exercise ECG testing alone: How to decide.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Non-invasive assessment of low- and intermediate-risk patients with chest pain.Trends in cardiovascular medicine · 2017Review
- Serious and potentially life threatening complications of cardiac stress testing: Physiological mechanisms and management strategies.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Review of cardiovascular imaging in The Journal of Nuclear Cardiology in 2014: Part 2 of 2: Myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Regadenoson-induced bradycardia and hypotension: possible mechanism and antidote.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Regadenoson for myocardial perfusion imaging: Is it safe?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Serious complications associated with regadenoson administration for myocardial perfusion imaging: a commentary.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Regadenoson administration and QT interval prolongation during pharmacological radionuclide myocardial perfusion imaging.Indian heart journalObservational
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regadenoson is a selective A2A receptor agonist approved for use as a pharmacologic stress agent for myocardial perfusion imaging after several multicenter trials demonstrated its equivalence in diagnostic accuracy for the detection of coronary artery disease and a decreased incidence of serious side effects as compared to adenosine. Recently, the FDA released a safety announcement advising of the rare but serious risk of heart attack and death associated with regadenoson and adenosine in cardiac stress testing, particularly in patients with unstable angina or cardiovascular instability. We report two cases of asystole with hemodynamic collapse in stable outpatients soon after receiving a standard regadenoson injection. The prevalence of potentially life threatening bradycardia, including asystole, associated with the use of regadenoson may be greater than previously expected. These cases highlight the need for cardiac stress labs to anticipate the potential for serious side effects with all patients during the administration of coronary vasodilators.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.